Capravirine, a new non-nucleoside reverse transcriptase inhibitor, undergoes extensive oxygenation reactions, including N-oxidation, sulfoxidation, sulfonation, and hydroxylation in humans. Numerous primary (mono-oxygenated) and sequential (di-, tri-, and tetraoxygenated) metabolites of capravirine are formed via the individual or combined oxygenation pathways. In this study, cytochrome P450 en...

Penyebaran Covid-19 yang sangat cepat menyebabkan pemerintah memberlakukan berbagai kebijakan untuk mengantisipasi cepatnya penyebaran Covid-19. Sumatera Utara khususnya kota Medan telah ditetapkan dalam zona Merah dikategorikan resiko tinggi. Oleh karena itu perlu dilakuka pemeriksaan (screening) pada karyawan Universitas Sari Mutiara Indonesia. Tujuan kegiatan ini adalah mendeteksi secara din...

We have identified numerous Ancestral Haplotypes encoding a 14-Mb region of Bota C19. Three are frequent in Simmental, Angus and Wagyu and have been conserved since common progenitor populations. Others are more relevant to the differences between these 3 breeds including fat content and distribution in muscle. SREBF1 and Growth Hormone, which have been implicated in the production of healthy b...

Arthrobacter sp. 10137 has been used to produce b-fructofuranosidase (FFase). Sucrose and corn steep powder in an optimized ratio of 10:1 were the best carbon and nitrogen sources for enzyme production in a shake flask. The maximum FFase activity was 26.69 U/mL after 22.5 h in batch culture, and the crude FFase, obtained by ultrafiltration and (NH4)2SO4 fractionation, was purified about 7-fold ...

Wastes produced during fermentation and distillation of crude sugarcane juice in rum factories were evaluated as a new source of waxes. The chemical composition of the crude wax extracted from adsorbat of the wastes on fuller's earth was studied by GC-mass spectrometry. Series of linear alkanes (C19-C33), and wax esters constitute the main components. In addition, phytosterols, triterpene methy...

Since March 2020 the Amphia Hospital, Breda in Netherlands has been at forefront of patient care during COVID-19 pandemic. To assist health professionals and researchers we initiated a task force to optimize related research by coordinating scientific projects promoting collaboration between different disciplines Hospital. Within three separate teams were formed with their own dedicated tasks r...