BACKGROUND Patients with coronary artery disease (CAD) are known to have several lipoprotein abnormalities. We examined plasma cholesterol concentrations of major lipoproteins and their subclasses, using a gel permeation HPLC, to establish an association between a lipoprotein subclass pattern and the presence of CAD. METHODS We performed a simple and fully automated HPLC, followed by mathemat...

BACKGROUND AND PURPOSE Expert consensus guidelines recommend low-density lipoprotein cholesterol as the primary serum lipid target for recurrent stroke risk reduction. However, mounting evidence suggests that other lipid parameters might be additional therapeutic targets or at least also predict cardiovascular risk. Little is known about the effects of nontraditional lipid variables on recurren...

Dyslipidemia is implicated in increased cardiovascular risk associated with chronic kidney disease (CKD) and in the progression of renal damage. This study compared 4 different lipid-related ratios (total cholesterol [TC]/high-density lipoprotein cholesterol [HDL-C], triglyceride [TG]/HDL-C, calculated low-density lipoprotein cholesterol [c-LDL-C]/HDL-C, and non-HDL-C/HDL-C ratio) for predictio...

BACKGROUND Several studies demonstrated an association of homocysteine plasma levels and the plasma lipoprotein profile. This cross-sectional pilot study aimed at analyzing whether blood levels of the two important cofactors of homocysteine metabolism, folate and vitamin B12, coincide with the lipoprotein profile. METHODS In a retrospective single center approach, we analyzed the laboratory d...

BACKGROUND Some coincidental disorders with migraine have been introduced that may have role in its pathogenesis or aggravation. In this study we determined the relative frequency of hyperlipidemia as a coincidental disorder in patients affected by migraine. METHODS A total of 102 migraine-affected patients according to International Headache Society (HIS) criteria and 103 control subjects ad...

Background. Abnormal lipid homeostasis in sickle cell disease (SCD) is characterized by defects in plasma and erythrocyte lipids and may increase the risk of cardiovascular disease. This study assessed the lipid profile and non-HDL cholesterol level of SCD patients. Methods. A hospital-based cross-sectional study was conducted in 50 SCD patients, in the steady state, aged 8-28 years, attending ...

INTRODUCTION A low level of high-density lipoprotein cholesterol (HDL-C) is an established predictor of the risk of coronary heart disease (CHD). HDL promotes cellular cholesterol efflux and reverse cholesterol transport from lipid-laden macrophages (Figure 1), and prevents lipoprotein oxidation. A linear inverse relation has been reported in many observational studies between plasma HDL-C leve...

cardiovascular disease (cvd) due to atherosclerosis is the foremost cause of premature mortality and of disability-adjusted life years (dalys) in developed and developing countries (1).  the associated mortality is  preventable through treatment of dyslipidemia (2). over half of the first chd events and 3/4 of chd deaths are preventable by controlling the risk factors, including diet, exercise,...