The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo s...

Objective: Coronary heart disease (CHD) is one of the most common diseases. Coronary angiography (CAG) is an important apparatus used to diagnose and treat this disease. Since angiography is performed through exposure to ionizing radiation, it can cause harmful effects induced by double-stranded breaks in DNA which is potentially life-threatening damage. The aim of the present study is to inves...

Background: The metaphase-spread-based dicentric chromosome assay (DCA) is the “gold standard” biodosimetry method for radiation dose assessment. However, practical issues influencing dose assessment by DCA, such as cell culture type and blood transport temperature are not addressed. Purpose: To fill the research gaps, we studied the effects of short-term cell culture type, the use of whole blo...

Adenovirus type 5 E1A has been implicated in mediation of tumor suppression. Preclinical gene therapy studies have additionally shown that complete growth suppression can be achieved by incomplete transfer of E1A into tumors, suggesting that a bystander effect may also be associated with E1A. In this study, we investigated the E1A-mediated bystander effect and the mechanisms that may be associa...

We have designed a targeted systemic suicide gene therapy that combines the advantages of tumor-selective gene expression, using the human telomerase promoter (hTERT), with the beneficial effects of an oncolytic adenovirus to deliver the gene for the prodrug-activating enzyme carboxypeptidase G2 (CPG2) to tumors. Following delivery of the vector (AdV.hTERT-CPG2) and expression of CPG2 in cancer...

background: after radiation therapy (rt), some health hazards including dna damages may occur where melatonin can play a protective role due to free radical generation. on the other hand, serious accidental overexposures may occur during rt due to nuclear accidents which necessitate the need for study on exposure to high-dose radiations during treatments. objective: the aim of this study was to...

Chronic lymphocytic leukemia (CLL) cells can be made to express recombinant CD40-ligand (CD154) by transduction with a replication-defective adenovirus vector (Ad-CD154). Ad-CD154-transduced and bystander leukemia cells become highly effective antigen-presenting cells that can induce CLL-specific autologous cytotoxic T lymphocytes in vitro. This study investigated the immunologic and clinical r...

Anacardic acid (6-pentadecylsalicylic acid, AA), a natural compound isolated from the traditional medicine Amphipterygiumadstringens, has been reported as potential antitumor agents in various cancers including prostate cancer (PC). However, the effects and mechanism of AA on the radiosensitivity of prostate cancer remains unknown. The results indicated that AA exhibited strong antitumor activi...

background: the omega-3 fatty acid (ω-3 fatty acid) such as eicosapentaenoic acid (epa) is currently used in the clinic as a nutritional supplement in the treatment of polycystic ovarian syndrome (pcos). the present study was designed to investigate the effect of epa on the expression levels of peroxisome proliferator-activated receptor gamma (pparγ) and cytochrome p450 aromatase (encoded by th...