Two essential aspects of virtual screening are considered: experimental design and performance metrics. In the design of any retrospective virtual screen, choices have to be made as to the purpose of the exercise. Is the goal to compare methods? Is the interest in a particular type of target or all targets? Are we simulating a 'real-world' setting, or teasing out distinguishing features of a me...

Recent developments in cognitive neuroscience radically changed the perspective on understanding human nature. For the first time in history many philosophical questions can be placed on scientific, rather than on philosophical grounds. These questions include understanding of the mind, self, free will, religious and cultural beliefs, morality, politics and social organization. Scientific conse...

We study identification in a class of linear rational expectations models. For any given exactly identified model, we provide an algorithm that generates a class of equivalent models that have the same reduced form. We use our algorithm to show that a model proposed by Jess Benhabib and Roger Farmer is observationally equivalent to the standard new-Keynesian model when observed over a single po...

The care and feeding of primates in captivity, be they human or other, seems based on a somewhat limited scientific basis. Observation of pathologies or limitations that have been related to nutritional or metabolic “misadventures” perhaps has been the foundation [1,2], at least in earlier times for design of “optimal diets.” That has changed from recommendations related to “four basic food gro...