Using a semiempirical quantum mechanical procedure (FCPAC) we have calculated the partial atomic charges of amino acids from 494 high-resolution protein structures. To analyze the influence of the protein's environment, we considered each residue under two conditions: either as the center of a tripeptide with PDB structure geometry (free) or as the center of 13-16 amino acid clusters extracted ...

Phenotypic plasticity is important in the evolution of traits and facilitates adaptation to rapid environmental changes. However, variation in plasticity at the individual level, and the heritable basis underlying this plasticity is rarely quantified for behavioral traits. Alternative behavioral reproductive tactics are key components of mating systems but are not often considered within a phen...

The article is devoted to the interpretation of one most famous lubok prints (cheap popular prints) Mice Are Burying Cat, which was printed in different editions and versions from beginning 18th century middle 19th century. plot this picture under discussion. Some researchers view it as a parody funeral Peter I, while others draw attention fact that stylistic features early images language capt...

Autism spectrum disorder (ASD) is a neurodevelopmental characterized by impaired social communication, poor interactions, and repetitive behaviors. We aimed to examine autism-like behaviors related gene expressions in rats exposed diesel exhaust (DE)-origin secondary organic aerosol (DE-SOA) perinatally. Sprague–Dawley pregnant were clean air (control), DE, DE-SOA the exposure chamber from gest...

36 human beings, of whom the youngest was one and a half years and the oldest 76 years old, fell victims to 16 multiple homicides each committed by one perpetrator. 7 of the homicides were committed outside the family and other lasting relationships. 9 homicides can be assigned to the group of "family tragedies". As far as the victims of the first group are concerned, the course of events in co...

The core behavioral symptoms of Autism Spectrum Disorders (ASD) include dysregulation of social communication and the presence of repetitive behaviors. However, there is no pharmacological agent that is currently used to target these core symptoms. Epigenetic dysregulation has been implicated in the etiology of ASD, and may present a pharmacological target. The effect of sodium butyrate, a hist...

We consider multi-chain protein native structures and propose a criterion that determines whether two chains in the system are entangled or not. The criterion is based on the behavior observed by pulling at both termini of each chain simultaneously in the two chains. We have identified about 900 entangled systems in the Protein Data Bank and provided a more detailed analysis for several of them...

HyperPuja is a novel controller that closely mimicks the behavior of a Tibetan Singing Bowl rubbed with a “puja” stick. Our design hides the electronics from the performer to maintain the original look and feel of the instrument and the performance. This is achieved by using wireless technology to keep the stick un-tethered as well as burying the electronics inside the the core of the stick. Th...

Pesticides can negatively affect insect immunity. Although studies show that Formosan subterranean termites, Coptotermes formosanus Shiraki, are resistant to microbial infections, the effects of pesticides on disease resistance is not well studied. In this study, C. formosanus previously fed lufenuron was exposed to each of the three entomopathogenic bacteria, Pseudomonas aeruginosa (Schroeter)...

Selective serotonin reuptake inhibitors (SSRIs) are the only effective pharmacological treatments for obsessive-compulsive disorder (OCD). Nonetheless, their generally limited efficacy, side-effects, and delayed onset of action require improved medications for this highly prevalent disorder. Preclinical and clinical findings have suggested serotonin2C (5-HT2C) receptors as a potential drug targ...