ObjectiveOur point is to determine if the treatment of the 3 degree burn wounds makes any difference if sprayed cultured autologous keratinocyte used alone or in combination with Fibrin glue. DesignAnimal experimental study. Animals30 male Wistar rats. ProceduresThirty male Wistar rats were selected and their keratinocytes were isolated and cultured from small skin biopsy. Rats were divided ran...

Burns are a prevalent and burdensome critical care problem. The priorities of specialized facilities focus on stabilizing the patient, preventing infection, and optimizing functional recovery. Research on burns has generated sustained interest over the past few decades, and several important advancements have resulted in more effective patient stabilization and decreased mortality, especially a...

A novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy). In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy on deep partial thickness burn wounds in rats were assessed. Skin samples were taken at 7, 14, 21,...

Burn injuries are a common and highly lethal trauma causing immense pain, suffering, disability, and unfortunately death. The secondary contracture can lead to loss of function and furthermore lifelong disability both physically and mentally. Stem cells have been used in a variety of clinical applications to repair and regenerate chronic wounds. However the use of stem cells in burns has just r...

The aim of the study was to assess the propolis effect on fibronectin metabolism in the course of burn wounds healing process. A model of burn wound healing of pig skin was applied. The amount of the released glycoprotein was assessed by a surface plasmon resonance. The profile of extracted fibronectin components was also assessed by an electrophoresis in polyacrylamide gel, with a subsequent i...

BACKGROUND Burn is still one of the most devastating injuries in emergency medicine while improvements in wound healing knowledge and technology have resulted into development of new dressings. This study was undertaken to evaluate the healing effect of licorice in Pseudomonas aeruginosa infected burn wounds of experimental rat model. METHODS One hundred and twenty female Sprague-Dawley rats...

Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey--products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathologic...

Background: In case of large burn injuries, split-thickness skin graft (STSG) is limited by donor skin availability. It is not possible to achieve an expansion of more than 1:9 using conventional STSG. Here we introduce Xpansion micrografting technique, which allows a substantially larger expansion ratio enabling adequate coverage of large wounds. Methods: Pre-clinical and clinical studies usin...

BACKGROUND Burn is still one of the most devastating injuries in emergency medicine while improvements in wound healing knowledge and technology have resulted into development of new dressings. This study was undertaken to evaluate the healing effect of licorice in Pseudomonas aeruginosa infected burn wounds of experimental rat model. METHODS One hundred and twenty female Sprague-Dawley rats ...

A major complication associated with burn injury is delayed wound healing. While healing of the burn injury site is essential, healing of distal injury sites caused by surgical interventions and other processes also is important. The impact of burn injury on healing of these distal wound sites is not understood clearly. To study this, mice were subjected to major burn injury or a sham procedure...