SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular responses to stress and in tumorigenesis through deacetylation of important regulatory proteins, including p53 and the BCL6 oncoprotein. Hereby, we describe the identification of a compound we named cambinol that inhibits NAD-dependent deacetylase activity of human SIRT1 and SIRT2. Consistent with the role of...

characteristics of uridineand methyl-labeled low molecular weight RNA (4S and. 5S) of human lymphoblasts from Burkitt lymphoma, infectious mononucleosis, and EB-virus transformed lymphocytes were compared with lymphoblasts from normal donors (cell line) and phytohernagglutinin (PHA)-transformed peripheral blood lymphocytes. No significant differences in these RNA profiles were found between the...

Burkitt lymphoma is endemic in the Equatorial Belt of Africa, its molecular hallmark is an activated, MYC gene mostly due to a chromosomal translocation. Especially in its endemic clinical variant, Burkitt lymphoma is associated with the oncogenic Epstein-Barr virus (EBV), and holoendemic malaria acts as an amplifier. Environmental factors may also cooperate in Burkitt lymphomagenesis in the en...

Formation of epithelioid histiocytic cell granulomas has been described in the post in various neoplasms, hematologic malignancies included. Among lymphoproliferative disorders such changes are commonly found in Hodgkin lymphoma and T-cell non-Hodgkin lymphomas (NHL), but are rarely described in B-NHL, like Burkitt lymphoma. This report presents a case of sporadic Burkitt lymphoma accompanied b...

P galactoside binding protein (PGBP) is a novel physiological regulator of the cell cycle secreted by mouse embryo fibroblasts (MEFs) [l]. Addition of PGBP to MEFs has been shown to induce cell cycle arrest. PGBP is a monomeric protein of 134 amino acids long. PGBP's cytostatic effect is independent of its carbohydrate-binding activity and it operates by binding to high affinity receptors on ta...

Two types of immunofluorescence tests are being applied to studies of Burkitt 's lymphoma. In one of these (1, 2), ceils from fresh biopsies or from certain lines of tumor cultures are stained vitally by the indirect technique, using sera of patients with this malignancy for the primary reaction. This test reveals surface antigens of tumor-derived cells which are not present in the membranes of...