microparticles offer various significant advantages as drug delivery systems, including: (i) an effective protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the possibility to accurately control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration (compared to alternative parenteral controlled release dosage ...

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

to improve drug selectivity toward target cells, one interesting approach for drug delivery is to use polymer nanoparticles. a two-layered oniom becke3- lyp: uff calculation was carried out to study the structural and thermodynamic properties of the interaction between acetamide derivatives and the pca-peg-pca copolymers. the interaction enthalpies and the gibbs free energies between acetamide ...

BACKGROUND The dilution and rapid elimination of topically applied drugs due to the flushing action of saliva is a major difficulty in the effort to eradicate infections of oral cavity. Utilization a proper delivery system for incorporation of drugs has a major impact on drug delivery and such a system should be formulated for prolonged drug retention in oral cavity. OBJECTIVES The aim of the...

nowadays, developements in nanotechnology have leeds an increased application of this newborn technology in cancer treatment. in this study, a stabilized micelle was developed to load hpd in order to be used in photodynamic treatment of cancer in an animal model. to construct micelles, pluronic p-105 was used and stabilized to encapsulate hpd . this process includes a 24 h polymerization in whi...

OBJECTIVE Betahistine dihydrochloride (BH.2HCl), an anti-vertigo histamine analog used in the treatment of Ménière's disease, undergoes extensive first-pass metabolism and suffers from short biological half-life. The aim of the present work was to develop and estimate controlled release mucoadhesive buccal tablets of BH.2HCl with a unidirectional drug flow to overcome this encumbrance. METHOD...

hydrogels are introduced to modem medicine as novel materials suitable for a variety ofbiomedical applications. studying hydrogels as novel biomaterials has become a fast-developingand exciting research field during the last two decades. these interesting biomaterials have found awide range of application including contact lenses, vehicles for drug delivery and scaffold in tissueengineering and...

The pharmaceutical industry is pursuing the development of thin films as a novel method drug administration. Thin an alternative to standard dosage forms have been described. They are very adaptable platform capable producing immediate, local, or systemic effects. Additionally, these systems self-administered, which advantageous for patients with dysphagia, elderly, pediatric, bedridden and tho...