A series of alkyl- and aryl-1,2,4-triazino[4,3-c]quinazolines (5a-h and 8a-h) were synthesized and characterized. The title compounds were evaluated for their in vivo bronchodilator activity on guinea pigs. All the test compounds exhibited good protection against histamine-induced bronchospasm. The structure-activity relationships based on the results obtained for these series were studied. Inc...

The incidence of asthma is increasing worldwide, but morbidity and mortality are decreasing because of improvements in medical care. Although the incidence of severe perioperative bronchospasm is relatively low in asthmatics undergoing anaesthesia, when it does occur it may be life-threatening. The keys to an uncomplicated perioperative course are assiduous attention to detail in preoperative a...

The inhalation of sodium cromoglycate (SCG) is an effective and widely used treatment for asthma. Rarely, reactions to this drug, such as pulmonary eosinophilia, allergic granulomatosis, anaphylaxis, angioneurotic oedema, urticaria, and skin eruptions, have been reported.' Although mild wheeze may develop in some patients after inhaling SCG, in only one patient has the provocation of severe bro...

The involvement of respiratory system occurs mainly as a result of a high spinal block. Our case describes the unusual effect of mid-spinal analgesia. We encountered bronchospasm in an otherwise healthy patient undergoing inguinal hernia repair under subarachnoid block. The highest level of block was T6. The anxiety of the patient further aggravated the symptoms. This is probably the first repo...

Sport is an essential part of childhood, with precious and acknowledged positive health effects but the impact of exercise-induced bronchoconstriction (EIB) significantly reduces participation in physical activity. It is important to recognize EIB, differentiating EIB with or without asthma if the transient narrowing of the airways after exercise is associated with asthmatic symptoms or not, in...

Tweinty-three asthmatic children had severe sudden bronchospasm due to numerous factors. Baseline values for the peak expiratory flow rate were less than 25 percent of predicted. Utilizing an analysis of variance, three methods of administering isoproterenol hydrochloride (hand-held Freon-propelled nebulization, continuous nebulization, and intermittent positive-pressure breathing [IPPB]) were ...

IN the perioperative period, anaphylactic reactions are often induced by the intravenous administration of muscle relaxants, antibiotics, colloids, and radiocontrast materials as well as after local contact with latexcontaining materials (e.g., gloves, catheters, airway tube) and chlorhexidine. Inhalation of toxic and highly irritant substances contained in cleaning solutions has occasionally b...

BACKGROUND Premedication with beta-2 agonists (e.g. salbutamol) is effective in preventing increases in total respiratory resistance and in decreasing the incidence of perioperative bronchospasm in asthmatic children. Because children with recent respiratory tract infection (RTI) exhibit bronchial hyperreactivity similar to that observed in asthmatic children, the use of salbutamol in children ...