Conclusion A titrated adenosine protocol with prophylactic use of an inhaled beta-2-agonist is a safe procedure in patients with history of mild, well-controlled asthma or COAD undergoing stress myocardial perfusion imaging. Figure 4A. Maximal flow-volume curve results showing mild airflow limitation. There was limited reversibility on bronchodilator response testing (40 ml (2%) increase in FEV...

STUDY OBJECTIVE Bronchodilator response criteria have been determined in adults; however, data applicable to children and adolescents are scarce. We measured pulmonary function in asthmatic patients to determine the bronchodilator response. DESIGN A blind study. SETTING Outpatient clinic of Pneumology Unit, Instituto da Crianca and Center of Asthma Care and Research, University Hospital, Un...

The efficacy of bronchodilator nebuliser solutions may be influenced by the presence of preservatives. In a double blind, randomised, crossover study the effect of preservatives in determining the airway responses to 5 mg of terbutaline was studied in a group of 21 atopic asthmatic patients. The presence of preservatives affected neither the bronchodilator action of terbutaline nor its protecti...

BACKGROUND It is unknown whether aggressive medication strategies should be used for early COPD with or without lung hyperinflation. We aimed to explore the characteristics and bronchodilator responsiveness of early COPD patients (stages I and II) with/without lung hyperinflation. METHODS Four hundred and six patients with COPD who performed both lung volume and bronchodilation tests were ret...

The present authors aimed to determine if the criteria for the diagnosis of chronic obstructive pulmonary disease (COPD) and its classification by severity as recommended by the Global Initiative for Chronic Obstructive Lung Disease are supported by measurements of respiratory health-related quality of life. A community-based sample of adults aged 25-75 yrs had pre- and post-bronchodilator spir...

BACKGROUND The hormone atrial natriuretic peptide (ANP) causes bronchodilation and partially protects against direct and indirect bronchial challenges. Both in vitro and in vivo studies have found that the protective effect of ANP against bronchoconstriction is enhanced by inhibition of the enzyme neutral endopeptidase (NEP). It was hypothesised that pretreatment with thiorphan, an NEP inhibito...

BACKGROUND The changes in inspiratory capacity (IC) over time in chronic obstructive pulmonary disease (COPD) patients are unknown. The Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT®) trial included IC measurements. METHODS IC analysis from UPLIFT® (N = 5992) was performed at 1 and 6 months, and every 6 months through 4 years. Annualized rate of decline in pre-...

Methods We used data from the BOLD-Australia study. Persons aged 40 years and over were randomly selected from the electoral roll, either directly or via a two stage sampling procedure, in centres based in four Australian States. Spirometry was performed before and after administration of salbutamol 200 μg, according to a standardised protocol with careful attention to quality control. Subjects...

BACKGROUND Total lung capacity (TLC), forced expiratory flow between 25 and 75% (FEF25-75%), peak expiratory flow (PEF), or post-bronchodilator volume response is recommended to detect obstructive abnormalities in the lung. The present study was performed to evaluate the usefulness of these pulmonary function test (PFT) parameters to diagnose obstructive lung disease in subjects with a restrict...

In "Notes on Asthma" published in 1873, John Thorowgood stated that "daily exercise in the open air should not be neglected, and several cases testify to the effect of a steady walk in preventing an attack of asthma even when it already threatens". Similarly, Salter (1868) suggested that he was "puzzled by the fact" that exercise appeared to help some of his patients. From what we know today, i...