Background: Fairly recent data highlight the role of programmed cell death and autoimmunity, as potentially important factors in the pathogenesis of chronic obstructive airway diseases. The purpose of our research was to determine the influence of apoptotic factors on the immunity of patients with atopic bronchial asthma according to the degree of severity. Method: The study was performed on th...

Aspirin-exacerbated respiratory disease (AERD) is a well-known clinical condition. Aspirin desensitization followed by daily aspirin therapy is the treatment of choice. We report a challenging case of primary cutaneous vasculitis following aspirin desensitization in a patient with AERD. The vasculitis was likely suppressed with higher dose systemic steroid use to control asthma. Aspirin desensi...

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic necrotizing vasculitis of small to medium-sized vessels associated antineutrophil cytoplasmic antibodies (ANCA). EGPA usually diagnosed in patients bronchial asthma (BA) and characterized by predominant lesion the lungs, skin, peripheral nervous system. ANCAs myeloperoxidase are detected 1/3 EGPA. Presence or absence differ...

Results Serum sCD23 was significantly increased (p<0.01) in bronchial asthma (1209.8 ± 68.01 pg/mL), bronchiolitis (1455.52 ± 146.92 pg/mL) and bronchial pneumonia (1406.35 ± 98.26 pg/mL) when compared to controls (691.5 ± 74.94 pg/mL). Serum IgE and blood histamine levels were increased significantly (P<0.05) and IFN-g (Th1 cytokine) was significantly lower (P<0.01) in both bronchial asthma an...

BACKGROUND Fairly recent data highlight the role of programmed cell death and autoimmunity, as potentially important factors in the pathogenesis of chronic obstructive airway diseases. The purpose of our research was to determine the influence of apoptotic factors on the immunity of patients with atopic bronchial asthma according to the degree of severity. METHOD The study was performed on th...

BACKGROUND Asthmatics in particular have a need for influenza vaccines because influenza infection is a frequent cause of hospitalization of patients with bronchial asthma. Currently, only inactivated influenza vaccines are recommended for influenza prevention in asthma sufferers. OBJECTIVE The aim of our study was to analyze and compare the effects of influenza infection and vaccination with...

Allergic rhinitis (AR) is one of the most common diseases in world, often combined with bronchial asthma. The lecture discusses modern ideas about mechanisms pathogenesis, diagnosis and treatment AR, which allows to develop a personalized approach patients AR.

Bronchial asthma and obesity are common medical problems as there are more than 300 million patients with bronchial asthma [1,2] and 2 billion obese and overweight subjects worldwide [3]. However, about 36% of American subjects were obese in 20092010 [4]. In this regard, association between obesity and asthma reduce responsiveness to steroid therapy, increase exacerbation of asthma and reduce c...

Background: Use of hormone replacement therapy (HRT) may increase the risk of adult-onset asthma in women. Various in vitro studies have reported that estradiol stimulates human mast cell lines causing release of allergic mediators which was not observed in estrogen receptor-alpha (ER-alpha) knockout mice. Thus, estrogen might be a key element in occurrence of asthma. In the present study, we p...

Exhaled nitric oxide (NO) concentration is a noninvasive measure of airway inflammation and is increased in asthma. Inhaled glucocorticoids decrease exhaled NO concentration, but the relative contributions of alveolar and bronchial levels to the decrease in exhaled NO concentration are unknown. Alveolar NO concentration and bronchial NO flux can be separately approximated by measuring exhaled N...