Benzylic zinc reagents prepared by direct insertion of zinc to benzylic chlorides in the presence of LiCl undergo smooth cross-coupling reactions with aromatic chlorides, bromides and tosylates using Ni(acac)(2) and PPh(3) as a catalyst system.

A simple and efficient strategy for the C–N cross-coupling of indazole with a variety substituted aryl bromides is reported. Under optimized conditions, broad scope N-arylated products were obtained in good to excellent yields (up 87%) under ligand-free conditions.

The three possible structural isomers of 4-(pyridyl)pyrimidine were employed for the synthesis of new pyrrolo[1,2-c]pyrimidines and new indolizines, by 1,3-dipolar cycloaddition reaction of their corresponding N-ylides generated in situ from their corresponding cycloimmonium bromides. In the case of 4-(3-pyridyl)pyrimidine and 4-(4-pyridyl)pyrimidine the quaternization reactions occur as expect...

Adenosine and uridine analogues functionalized with alkenyl or fluoroalkenyl chain at C5' were prepared employing cross-metathesis, Negishi couplings, and Wittig reactions. Metathesis of the protected 5'-deoxy-5'-methyleneadenosine or uridine analogues with six-carbon amino acids (homoallylglycines) in the presence of Grubbs catalysts gave nucleoside analogues with the C5'-C6' double bond. Alte...

The title salt, (C(19)H(18)NO(2))(2)[Cu(2)Br(6)], was obtained from an attempt to synthesize the copper(II) complex of 2,6-bis-(2-meth-oxy-phen-yl)pyridine (L) from a reaction between CuBr(2) and one equivalent of L in CH(2)Cl(2) at room temperature. The resulting compound is the salt of the 2,6-bis-(2-meth-oxy-phen-yl)pyridinium cation and 0.5 equivalents of a hexa-bromido-dicuprate(II) dianio...

We have found that bromo(triphenylphosphine)copper(I), an air-stable and soluble copper(I) complex, can be used as a catalyst in the synthesis of diaryl ethers. Using this catalyst, we have synthesized diaryl ethers from electron-rich aryl bromides and electron-rich phenols in the presence of cesium carbonate, in 17–24 h, in NMP. We also found that electron-deficient aryl bromides couple with p...

Bromides were formerly used for their sedative and anti-convulsant properties. The neuropsychiatric features of bromide intoxication have been recognized for many years (Barbour, Pilkington and Sargent, 1936). Carney (1971) described 5 cases of bromism and advocated stricter control on bromide preparations. Part III of the Medicine Act (1978) made potassium bromide available only by prescriptio...

Benzyl bromides and related molecules are among the most common substrates in organic synthesis. They are typically used as electrophiles in nucleophilic substitution reactions. These molecules can also be activated via single-electron-transfer (SET) process for radical reactions. Representative recent progress includes α-carbon benzylation of ketones and aldehydes via photoredox catalysis. Her...

The triethylamine promoted stepwise 1,3-dipolar cycloaddition reaction of N-phenacylbenzothiazolium bromides with nitroalkenes in ethanol resulted in a mixture of two isomeric tetrahydrobenzo[d]pyrrolo[2,1-b]thiazoles with cis/trans/cis- and all-trans-configurations. More importantly, the corresponding dihydrobenzo[d]pyrrolo[2,1-b]thiazoles can be selectively prepared in refluxing ethanol and t...

A group of biodegradable alanine-derived gemini quaternary ammonium salts (bromides and chlorides) with various alkyl chains and spacer lengths was tested for anti-adhesive and anti-biofilm activity. The strongest antifungal activity was exhibited by bromides with 10 and 12 carbon atoms within hydrophobic chains (N,N'-bis(1-decyloxy-1-oxopronan-2-yl)-N,N,N',N'-tetramethylpropane-1,3-diammonium ...