No therapeutically useful new classes of antibiotics have been identified in the past quarter of a century This has become of major consequence in the face of the increase in the incidence of significant antibiotic resistance in the past decade. Indeed, strains of several important pathogens have been identified for which very few, or even no, possibilities for antibiotic therapy exist. Althoug...

The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with a novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting transformed over non-transformed cells. The intriguing structure and biological activity of largazole have ...

Development of antivirals has focused primarily on vaccines and on treatments for specific viral agents. Although effective, these approaches may be limited in situations where the etiologic agent is unknown or when the target virus has undergone mutation, recombination or reassortment. Augmentation of the innate immune response may be an effective alternative for disease amelioration. Nonspeci...

In this paper‎, ‎we show the stability of Gustafson‎, ‎Weidmann‎, ‎Kato‎, ‎Wolf‎, ‎Schechter and Browder essential spectrum of bounded linear operators on Banach spaces which remain invariant under additive perturbations‎ ‎belonging to a broad classes of operators $U$ such $gamma(U^m)