background: differentiation, migratory properties and availability of mesenchymal stromal cells (msc) have become an important part of biomedical research. however, the functional heterogeneity of cells derived from different tissues has hampered providing definitive phenotypic markers for these cells. objective: to characterize and compare the phenotype and cytokines of adipose derived mscs (a...

to investigate the patterns of dna ploidy and proliferating activity in breast cancer and relate them to other prognostic factors, paraffin blocks of 53 cases of breast carcinoma were studied. cancer cells obtained by mechanical tissue disaggregation were examined for dna content, ploidy and s-phase fraction. dna assay was done using a cas interactive image analyzing system. all of the cases sh...

Objective(s): Development of molecules that specifically recognize cancer cells is one of the major areas in cancer research. Human epidermal growth factor receptor 2 (HER2) is specifically expressed on the surface of breast cancer cells. HER2 is associated with an aggressive phenotype and poor prognosis. In this study we aimed to isolate RNA aptamers that specifically bind to HER2 overexpressi...

the role of antioxidants in prevention and treatment of cancers have been reported by several studies. in our investigation we studied the effects of ascorbic acid, ?-tocopherol, and sodium selenite on proliferation of two breast cancer cell lines: t47d (estrogen-receptor positive) and mda-mb-231 (estrogen-receptor negative). we also used 17-?-estradiol as positive control for proliferation of ...

psa is a 33-kda serine protease that is produced predominantly by prostate epithelium. however, it has been shown that about 30-40% of female breast tumors produce psa and its production is associated with the presence of estrogen and progesterone receptors. we have now developed a new tissue culture system to study psa production in breast cancer and its association with prognostic factors suc...

Objective(s): The Janus kinase-signal transducers and activators of transcription signaling pathway (JAK/STAT pathway) play an important role in proliferation of breast cancer cells. Previous data showed that inhibition of STAT3 suppresses the growth of breast cancer cells, but the associated mechanisms are not well understood. This study aims to investigate the effect and associated mechanisms...

background: norepinephrine plays a trophic role in the control of cell replication and differentiation in target cells that express adrenergic receptors. methods: in this study, we have tested the influence of infraphysiological, physiological and supraphysiological concentrations (0.0001 nm, 1 nm, 10000 nm) of human norepinephrine on the proliferation of breast cancer cells (human breast adeno...

Studies show that cancer cell invasion or metastasis is the primary cause of death inmalignancies including breast cancer. The existence of cancer stem cells (CSCs) in breast cancermay account for tumor initiation, progression, and metastasis. Recent studies have reporteddifferent effects of cannabinoids on cancer cells via CB1 and CB2 cannabinoid receptors. In thepresent study, the effects of ...

Studies show that cancer cell invasion or metastasis is the primary cause of death inmalignancies including breast cancer. The existence of cancer stem cells (CSCs) in breast cancermay account for tumor initiation, progression, and metastasis. Recent studies have reporteddifferent effects of cannabinoids on cancer cells via CB1 and CB2 cannabinoid receptors. In thepresent study, the effects of ...