conclusions the increasing cell toxicity, apoptosis-inducing effects and decreasing telomerase activity may play an important role in the valproic acid and radiation mechanism. the current survey suggested that it is likely beneficial to combine valproic acid and gamma radiation to treat breast cancer. results combination of valproic acid and gamma radiation increased significantly cell toxicit...

the aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates spion and gemcitabine in plga±peg to form multifunctional drug delivery system. for this aim, super paramagnetic iron oxide nanoparticles (spions) were synthesized and encapsulated simultaneously with gemcitabine (gem) in plga±peg copolymers via w/o/w double emulsification method. optimum size and enca...

interaction between urokinase-type plasminogen activator (upa) and its receptor (upar) plays an important role in the progression of numerous cancer types including breast cancer by promoting tumor initiating,  proliferation,  invasion  and  metastasis.  hence,  disruption  of  this  interaction  inhibits  their downstream cascades and subsequently tumor growth. for this, we created two series ...

Parthenolide is a secondary metabolite, which naturally occurs in the feverfew plant and is responsible for its healing power. The potential of parthenolide in inhibition of cancer cell growth, alone or in combination with other anti-cancer therapeutics, have been studied in several laboratories. In this study, the effect of extracted parthenolide on the expression of seven pro-apoptotic genes,...

background: ß-carbolines, harmaline and harmine, are the major alkaloids presenting in the seeds of the peganum harmala l. these alkaloids are known as herbal active principals with potential use in pharmaceutical and medicine. objectives: to assess the growth inhibitory effect of phyto-alkaloids, harmaline and harmine, on cancer cell lines. methods: the p. harmala l.’s alkaloids were extracted...

In vitro studies on cancer cell lines still constitutes a major part of cancer research. It is very important that the researchers consider the importance of basic conditions of working with different cell lines. To the best of authors knowledge, this study is the first one to report the effect of seeding density on the growth curve of three human cancer cell lines. These cell lines include hum...

In continuation of previous research, the anticancer screening formulation herbal syrup Vinca extract was performed. The performed as per reported literature method. cancer on two Human cell lines. These lines were Lung Cancer line A549 and Breast Cell MCF7. found to be devoid properties.

background: tumour suppressor genes such as tp53, brca1 and rad51 are involved in dna repair and their malfunctions result in genomic instability and cancer. wild type (wt) tp53 binds to brca1and rad51 in vivo and in vitro. however, mutated tp53 in tumours can interfere with wt tp53 function. we studied how mutation of tp53 in mda-mb-468 cell line could affect its binding capacity and interfere...

objective: nucleostemin (ns) is a recently identified gene that is expressed mainly in the nucleoli of neuronal, embryonic and mesenchymal stem cells which plays a role in their self renewal. over expression of this gene has been reported in several cancer cell lines tumoral tissues including gastric, hepatic and prostate cancer. in this study, we investigated the effects of suppression of this...