DNA double-strand breaks (DSBs) are the most dangerous form of DNA damage and can lead to death, mutation, or malignant transformation. Mammalian cells use three major pathways to repair DSBs: homologous recombination (HR), classical nonhomologous end joining (C-NHEJ), and alternative end joining (A-NHEJ). Cells choose among the pathways by interactions of the pathways with CtIP and 53BP1. HR i...

In the physical vacuum of QCD, the energy density of lightquark fields strongly coupled to slowly varying gluon fields can be negative. The states that drive this energy density lowest are condensates of pairs of quarks and antiquarks of nearly opposite momenta. These quark-antiquark condensates break chiral symmetry. They may also affect other features of hadronic physics, such as the range of...

We consider the issue of testing a time series for a unit root in the possible presence of a break in a linear deterministic trend at an unknown point in the series. We propose a new break fraction estimator which, where a break in trend occurs, is consistent for the true break fraction at rate Op(T). Unlike other available estimators, however, when there is no trend break our estimator converg...

Desendan nekrotizan mediastinit boyundan başlayıp mediastene yayılan nadir ve ölümcül bir mediasten infeksiyonudur. Hastanın kurtarılmasını sağlayan anahtar noktalar erken tanı, agresif drenaj ve komplikasyonların dikkatli bir şekilde tedavisidir. Odontojenik kökenli, hemorajik komplikasyon gelişen ve başarılı bir şekilde tedavi edilen desendan nekrotizan mediastinit olgusunu sunuyoruz. Anahtar...

Bu çalışmada sayısal işaret işleme sistemlerinde yaygım olarak kullanılan iki boyutlu doğrusal dönüşümlerin çarpıcı kullanmadan gerçekleştirilmesini sağlayan bir algoritma geliştirilmiştir. Toplayıcı sayısında, orijinal sayıdan yüzde doksanlara varan kazanç elde edilmiştir.

Abstract:In this study, an effort has been made to determine the influence of rotational speed of tool on themicrostructure and hardness values of friction stir welded 2024-T851 aluminum alloy. The microstructure of stir zonein the joints has been investigated. It was found that the particles such as Al6(CuFeMn) particles are broken up duringfriction stir welding, and the degree of break up of ...

ÖZET Bu çalışmada, sonlu bir aralıkta verilmiş sınırsız operatör katsayılı ikinci mertebeden diferansiyel operatörün düzenli izi için bir formül bulunmuştur. Anahtar Sözcükler: Hilbert uzayı, Kendine eş operator, çekirdek operatör ABSTRACT In this work; a formula for the regularized trace of second order differential operator, which is given in a finite interval and with unbounded operator coef...

Recombination-dependent DNA replication, often called break-induced replication (BIR), was initially invoked to explain recombination events in bacteriophage but it has recently been recognized as a fundamentally important mechanism to repair double-strand chromosome breaks in eukaryotes. This mechanism appears to be critically important in the restarting of stalled and broken replication forks...