BACKGROUND As schizophrenia patients are typically suspicious of, or are hostile to changes they may be reluctant to accept generic substitution, possibly affecting compliance. This may counteract drug costs savings due to less symptom control and increased hospitalization risk. Although compliance losses following generic substitution have not been quantified so far, one can estimate the possi...

Introduction While various criteria exist to define or categorize innovative medicines as new repurposed, our knowledge there are no standardized systems that sufficiently capture the range of pipeline products. The National Institute for Health and Care Research Innovation Observatory (NIHR IO) undertakes routine horizon scanning support health technology assessment (HTA) in England maintains ...

A puzzling feature of pharmaceuticals markets is that sellers of branded drugs will, sometimes, sell generic versions of their own branded products, either directly or through license agreements. This paper proposes a new theoretical rationale for the fact that the introduction of these pseudogenerics may have anti-competitive effects. In a model that combines horizontal and vertical product di...

The authors develop a conceptual model of factors that determine behavioural intentions to buy co-branded products. The model is an extension of the Simonin/Ruth model. Structural equation modelling serves to test the hypotheses. Product fit has the strongest effect (of the exogenous factors) on behavioural intention. Marketers should gain a detailed understanding of consumers’ perceptions of p...

OBJECTIVE To determine whether smokers smoking from packs required under Australia's plain packaging law had different smoking beliefs and quitting thoughts, compared with those still smoking from branded packs. DESIGN Cross-sectional survey during the roll-out phase of the law, analysed by timing of survey. SETTING Australian state of Victoria, November 2012. PARTICIPANTS 536 cigarette s...

OBJECTIVES Cipla Pharmaceuticals have developed generic fixed-dose combinations of stavudine, lamivudine and nevirapine for HIV-infected children (Pedimune Baby and Junior). We determined the pharmacokinetic profiles of stavudine, lamivudine and nevirapine in Pedimune and compared these with the branded products. METHODS This Phase I, comparative, single-centre, open-label, three-period, sing...

BACKGROUND As in other societies, pharmaceutical expenditures in the Netherlands are rising every year. As a consequence, needs for cost control are often expressed. One possible solution for cost control could come through increasing generic substitution by pharmacists. We aim to analyse the extent and nature of substitution in recent years and estimate the likelihood of generic or branded sub...

injection is one of the most common medical procedures in the health sector. annually up to 16 billion injections are prescribed in low- and middle-income countries (lmics), many of them are not necessary for the patients, increase the healthcare costs and may result in side effects. currently over 40% of outpatient prescriptions in iran contain at least one injectable medicine. to address the ...

OBJECTIVES To evaluate the long-term cost-effectiveness of ticagrelor and ASA versus generic and branded clopidogrel and ASA in patients with ACS based on a Thai cost database. METHODS A one-year decision tree and a long-term Markov model were constructed to estimate lifetime costs and quality-adjusted life years (QALYs). For the first year, data from PLATO (NCT00391872) were used to estimate...