This paper presents a new architecture of neural networks designed for pattern recognition. The concept of induction graphs coupled with a divide-and-conquer strategy defines a Graph of Neural Network (GNN). It is based on a set of several little neural networks, each one discriminating only two classes. The principles used to perform the decision of classification are : a branch quality index ...

Cadmium (Cd) causes generation of reactive oxygen species (ROS) that trigger renal tubular injury. We found that rapamycin, an inhibitor of mTORC1, attenuated Cd-induced apoptosis in renal tubular cells. Knockdown of Raptor, a positive regulator of mTORC1, also had the similar effect. However, rapamycin did not alter generation of ROS, suggesting that mTORC1 is a target downstream of ROS. Indee...

We have shown previously that oxidized phospholipids (OxPLs), known to accumulate in atherosclerotic vessels, stimulate angiogenesis via induction of autocrine mediators, such as vascular endothelial growth factor (VEGF). We now address the pathways mediating up-regulation of VEGF in human endothelial cells treated with OxPLs. Analysis of structure-function relationship using individual species...

Laparoscopic cholecystectomy has resulted in various bile duct injuries. Treatment of these injuries is usually difficult and often leads to an intractable clinical course. We herein present a case of isolated right anterior sector (RAS) duct injury induced by laparoscopic cholecystectomy. The bile duct injury was successfully treated by hepatic atrophy induction. Imaging studies revealed that ...

background: several echocardiographic markers have been introduced to assess the left ventricular (lv) mechanical dyssynchrony. we studied dyssynchrony markers and the latest lv activation site in heart failure patients with and without left bundle branch block (lbbb). methods: conventional echocardiography and tissue velocity imaging were performed for 78 patients (lv ejection fraction ≤ 35%),...

blocking antibodies are valuable tools for inhibiting the specific receptor- ligand interactions. the interaction of co-stimulatory molecules on the antigen presenting cells with their ligands on t cells is an essential step for t cell activation. in the present study, the effect of blocking antibody against cd40 on its t cell stimulatory potential is investigated. the dcs (dendritic cells) wer...

The incidence of sustained bundle branch reentrant (BBR) tachycardia as a clinical or induced arrhythmia or both continues to be underreported. At our institution, BBR has been the underlying mechanism of sustained monomorphic ventricular tachycardia in approximately 6% of patients, whereas mechanisms unrelated to BBR were the cause in the rest. Data gathered from 20 consecutive patients showed...

A 52-year-old male patient, a former competitive athlete, was admitted to the hospital because of recurrent episodes of palpitations and presyncope, which occurred while he was running in the course of the previous 12 months. Family history was significant for a first-degree cousin who received an implantable cardioverter-defibrilla-tor (ICD) at 38 years of age because of an unclassified cardio...