background : this study compared the efficacy of two commonly used fractionation schedules for palliative whole brain irradiation in patients with brain metastases, and assessed the association of the radiotherapy therapy oncology group (rtog) recursive partitioning analysis for brain metastases (rpa) to survival with each schedule. methods : patients with multiple (more than three) brain metas...

background oxygen therapy, as a therapeutic modality, can be used for long periods of times. however, it may be accompanied by potential complications and side effects. objectives to evaluate the side effects of normobaric oxygen therapy in rabbits. materials and methods in a double-blind experiment, 28 white new zealand rabbits were randomized into an oxygen treatment group (n = 14) and a cont...

alzheimer disease (ad) is a neurodegenerative disorder marked by cognitive and behavioral impairment. amyloid beta (aβ) peptides are involved in ad as the main component of amyloid plaques found in the brain. recent in vivo and in vitro studies have shown that there is a lot of substances that alter aβ pathogenesis of ad. aβ induces toxicity lead to increasing ros. in the other hand, 5-ht6 and ...

Background and Objective: Chronic arsenic toxicity is a widespread problem; the role of brain oxidative stress has been suggested in the genesis of epilepsy and in the post-seizure neuronal death. However, studies investigating the effects of arsenic on seizure and related mechanisms are limited. The purpose of this study was to examine the effect of prolonged exposure to sodium arsenite on oxi...

BACKGROUND Topotecan is able to cross the blood-brain barrier (BBB) and has been demonstrated to be active in brain metastases from small cell lung cancer (SCLC). PATIENTS AND METHODS The aim of this study was to evaluate the efficacy and toxicity of topotecan at a dosage of 1.5 mg/m2 for 5 consecutive days every 3 weeks in patients with brain metastases from various neoplasms. RESULTS Amon...

background: silymarin is a flavonolignan that has been the subject of research to evaluate the beneficial properties for decades. silymarin has been known for its potent cytoprotective, hepatoprotective and antioxidant activities. the goal of the present study was to gain a deeper understanding of possible molecular mechanisms of apoptosis of the injuries induced by silymarin on balb/c mice fet...