traumatic brain injury (tbi) is one the most common cause of disability between young adults. these people have been socially isolated during post-surgery traumatic brain injury. in this study we investigated the effect of social isolation on the structural deficits after tbi in the young rats. young rats were divided into control group with social interaction, sham group with social isolation ...

GPR37 is an orphan G protein-coupled receptor (GPCR) implicated in several neurological diseases and important physiological pathways the brain. We previously reported that its long N-terminal ectodomain undergoes constitutive metalloprotease-mediated cleavage shedding, which have been rarely described for class A GPCRs. Here, we demonstrate protease cleaves at Glu167?Gln168 a disintegrin metal...

Background: Brain tumors in the cerebellum site, especially in the cranial nuclei, are most commonly associated with cognitive impairment in children, but the differences in dimensions of cognitive impairments in pediatric benign and malignant tumors are rarely studied. Meanwhile, cognitive impairments in this area are required to be widely studied. This study aimed at using Computerized Addenb...

We have discovered a non-AT(1), non-AT(2) angiotensin binding site in rodent and human brain membranes, which, based on its pharmacological/biochemical properties and tissue distribution, is different from angiotensin receptors and key proteases processing angiotensins. In this study, the novel angiotensin binding site was localized to a specific brain cell type by using radioligand receptor bi...

objective(s):estrogen (e2) has neuroprotective effects on blood-brain-barrier (bbb) after traumatic brain injury (tbi). in order to investigate the roles of estrogen receptors (ers) in these effects, er-α antagonist (mpp) and, er-β antagonist (phtpp), or non-selective estrogen receptors antagonist (ici 182780) were administered. materials and methods: ovariectomized rats were divided into 10 gr...

Introduction Brain trauma is one of the most common causes of hospitalization, disability, and mortality of people aged 15 to 74 years in nowadays societies. On the other hand, nowadays, different categories of stem cells are used to treat different kinds of diseases. BM-MSCs, are center of scientific research because of their high differentiation and proliferation ability. Methods:  Stem cel...

Monovalent and divalent cations competitively displace tetrodotoxin and saxitoxin (STX) from their binding sites on nerve and skeletal muscle Na channels. Recent studies of cloned cardiac (toxin-resistant) and brain (toxin-sensitive) Na channels suggest important structural differences in their toxin and divalent cation binding sites. We used a partially purified preparation of sheep cardiac Na...

Context Although endometrial cancer is the fourth most common malignancy in women, dissemination to brain an exceptional event course of disease. The aim this review determine important surgical prognostic factors for patients with metastatic brain. Materials and methods Report two cases. Medline database was used conduct a systematic literature from inception December 2020 looking English-lang...