background: aggressive personality changes are one of the most prevalent neuropsychiatric disorders after traumatic brain injury (tbi). it may lead to serious impairments in social relations and affect rehabilitation process. present research was performed to identify the determinant factors of personality change of aggressive characteristics after tbi. methods: 238 tbi patients (195 men and 43...

Objective(s) Cytokines such as IL-1β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1β after traumatic brain injury (TBI) in male rats. Materials and Methods Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations ...

Traumatic brain injury (TBI) is described as a situation in which the brain is damaged by an external force. It is considered to be a chief problem in health care. Pharmacotherapy and stem cell therapy are the main treatments used in TBI. The purpose of these procedures is to control the inflammation in injured regions of brain. Currently, there is no effective care for TBI that could regenerat...

Abstract Objective The present study examined the differential effect of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on neuropsychological functioning in children with traumatic brain injury (TBI) relative to orthopedic (OI). Method Participants were drawn from a prospective, longitudinal who sustained TBI (n = 69) or OI 72) between 3 and 7 years age. Children completed batte...

Traumatic brain injury (TBI) is a serious neurodisorder commonly caused by car accidents, sports related events or violence. Preventive measures are highly recommended to reduce the risk and number of TBI cases. The primary injury to the brain initiates a secondary injury process that spreads via multiple molecular mechanisms in the pathogenesis of TBI. The events leading to both neurodegenerat...

OBJECTIVE To examine how pre-traumatic brain injury (TBI) variables and TBI-related characteristics predict post-TBI criminal arrest, using longitudinal data from the Traumatic Brain Injury Model System National Database. SETTINGS Medical hospitals; rehabilitation facilities. PARTICIPANTS Participants with documented TBI and nonmissing Traumatic Brain Injury Model System data, resulting in ...

Traumatic brain injury (TBI) is characterized by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The primary insult to the brain initiates secondary injury cascades consisting of multiple complex biochemical responses of the brain that significantly influence the overall sever...

Traumatic brain injury (TBI) is a common, preventable, and disabling health condition with heterogeneous aetiology, type, severity, and outcomes. Ongoing challenges in TBI care are reflected by rapidly growing literature in the prevention, assessment and treatment of TBI, especially in sports concussion and blast-related TBI. Recent advances include TBI modelling, to predict outcomes of TBI and...

Background & Aim: Traumatic brain injury is one of the main causes of death and disability. The aim of this study is to systematically review the articles which assessed some serum factors of traumatic brain injury patients in relation to their outcomes. Methods & Materials/Patients: Databases were searched for relevant publications from 2005 to 2014. Selection criteria were:Studies which ev...

A 53-year-old male with history of traumatic brain injury (TBI) presented localized dissociative amnesia following a second head injury. While memory loss due to TBI is present in the literature, presentations this type are very rare. Although fully independent activities daily living, patient demonstrated severe deficits visual and processing speed upon neurocognitive evaluation. Effort testin...