brain tumors. Shortly thereafter, a clinical trial was initiated at the Brookhaven National Laboratory in cooperation with Sweet and others at the Massachusetts General Hospital utilizing borax as the capture agent (5, 6). The objective at that time was to use BNCT as an adjunct to surgery for the treatment of patients with the most highly malignant and therapeutically refractory of all brain t...

Preclinical studies for boron neutron capture therapy (BNCT) using epithermal neutrons are ongoing at several laboratories. The absorbed dose in tumor cells is a function of the thermal neutron flux at depth, the microscopic boron concentration, and the size of the cell. Dosimetry is therefore complicated by the admixture of thermal, epithermal, and fast neutrons, plus gamma rays, and the array...

Neutron diffraction has been used for engineering applications for nearly three decades. The basis of the technique is powder diffraction following Bragg’s Law. The measured diffraction patterns provide information about internal strains, texture and microstructure, which can be deduced from the peak positions, peak intensities, and peak widths, respectively. Most structural materials are aniso...

Recent advances in the ability to deliver boron-containing drugs to brain tumors have generated interest in -4 MeV liiacs as sources of epithemtal neutrons for radiation therapy. In addition, fast neutron therapy facilities have been studying methods to moderate their beams to take advantage of the high cross section for epithennal neutrons on boron-10. This paper describes the technical issues...

PURPOSE There is a clear need for a technique that provides subcellular locations of fluorine and boron atoms from fluorinated neutron capture agents because positron emission tomography is being tested as a tool for providing tumor boron concentrations in boron neutron capture therapy. EXPERIMENTAL DESIGN Ion microscopy was used in combination with confocal laser scanning microscopy to inves...

The efficacy of boron neutron capture therapy depends on the selective delivery of 10B to the target. Integrins αvβ3 are transmembrane receptors over-expressed in both glioblastoma cells and its neovasculature. In this study, a novel approach to dual-target glioblastoma vasculature and tumor cells was investigated. Liposomes (124 nm) were conjugated with a αvβ3 ligand, cyclic arginine-glycine-a...

Background: The aim of this work was to establish how well gel dosimeters performed, as substitutes for brain tissue compared with standard phantom materials such as water, polymethyl-methacrylate (or PMMA), A150 plastic and TE- liquid phantom material for dosimetry of neutron beams in boron neutron capture therapy. Materials and Methods: Thermal neutron fluence, photon dose and epithermal neu...

Findings of laser-assisted atom probe tomography experiments on boron carbide elucidate an approach for characterizing the atomic structure and interatomic bonding of molecules associated with extraordinary structural stability. The discovery of crystallographic planes in these boron carbide datasets substantiates that crystallinity is maintained to the point of field evaporation, and character...