BACKGROUND Repeated immunizations with polysaccharide (PS) vaccines cause hyporesponsiveness through undefined mechanisms. We assessed the effects of a PS booster on immune responses, frequency, and survival of PS-specific B-cell subpopulations in spleen and bone marrow. METHODS Neonatal mice were primed with meningococcus serotype C (MenC) conjugate MenC-CRM(197)+CpG1826, boosted with MenC-C...

OBJECTIVE To determine whether state booster seat laws were associated with decreased fatality rates in children 4 to 7 years of age in the United States. METHODS Retrospective, longitudinal analysis of all motor vehicle occupant crashes involving children 4 to 7 years of age identified in the Fatality Analysis Reporting System from January 1999 through December 2009. The main outcome measure...

We have studied the effect of the immunosuppressive agent cyclosporin on collagen induced arthritis in mice. Cyclosporin, when given prophylactically, was capable of suppressing the development of collagen induced arthritis and the immunological response to native type II collagen in a dose dependent manner. Furthermore, treatment with cyclosporin, started on the same day as the booster injecti...

Serological response to cholera revaccination has been studied in a semi-closed community consisting of individuals mostly in the 2-20-years age-group. The subjects had been inoculated against cholera every year at the beginning of the local epidemic season. Pre- and post-vaccination sera were obtained from 29 subjects inoculated with cholera vaccine (test group) and 28 from subjects inoculated...

Background: Booster dose for COVID-19 vaccine is being administered by many countries and has recently been started India special groups. Hence, it important to understand the willingness of people receive booster factors associated with it.Methods: The present study was a community based Online Cross-sectional done using internet social media applications period 10 days from 6th January 15th 2...

BACKGROUND Streptococcosis is an important disease of tilapia throughout the world. In Malaysia, streptococcosis outbreak was commonly reported during the 3-month period of high water temperature between April and July. This study describes the duration of protection following single and double booster dose regimes against streptococcosis in tilapia using a feed-based vaccine containing formali...

A modern web-hosting site is designed to handle load that is sometimes an order of magnitude greater than the average load. Such a site can be expensive and is underutilized most of the time. We describe a design and performance study of the web booster architecture, which reduces web server load during peak periods. A web booster, inserted between client and server, instantaneously decreases s...

The results of the administration to healthy beagles of a secondary antigenic stimulus (booster dose) of Leptospira canicola and infectious canine hepatitis virus (ICH) are reported. Twelve previously vaccinated animals were used. Six were exposed to a 335 r dose of x-irradiation. Three controls and three irradiated dogs received the booster dose two days after the irradiation and the remaining...

OBJECTIVE Work breaks are underutilized opportunities to promote health. The Booster Break program is a co-worker led physical activity group session devoted exclusively to standard 15-minute work breaks. The purpose of this study was to report the fidelity, attendance, feasibility, and sustainability of the Booster Break program and to explore its potential impact. PARTICIPANTS The study sit...