This paper reviews the clinical and experimental findings on the effects of sodium fluoride (NaF) on human and animal bone. NaF has been shown to cause a significant increase in axial skeletal bone mass. However, there is concern that the new bone may not provide the desired increase in bone strength. Yet, NaF remains the most commonly used agent capable of stimulating bone formation in most pa...

This review considers the definition of a healthy bone phenotype through the life course and the modulating effects of muscle function and nutrition. In particular, it will emphasise that optimal bone strength (and how that is regulated) is more important than simple measures of bone mass. The forces imposed on bone by muscle loading are the primary determinants of musculoskeletal health. Any f...

With age in degenerative effects on the skeletal system there is increase in the risk of fracture. Mechanical strength of human bone depends on chemical constituents present in it. The present investigation focuses on estimation of bone inorganic constituents: calcium, phosphor and determination of mechanical strength: tensile, compression. Further a correlation is developed to establish relati...

We studied the effects of high-dose irradiation on the mechanical properties and morphology of cortical bone in rabbits for 52 weeks after a single dose of 50 Gy of electron-beam to the tibia. After four weeks, the bending strength of the irradiated bone was unchanged, but at 12 weeks, the strength had decreased significantly. At 24 weeks after irradiation mean strength was less than half of co...

Atraumatic fractures of the skeleton in osteoporotic patients are directly related to a deterioration of bone strength. However, the failure of the bone tissue to withstand functional load bearing cannot be explained as a simple decrease in bone mineral density (quantity); strength is also significantly dependent upon bone quality. While a formal definition of bone quality is somewhat elusive, ...

Bone mineral density [BMD] generally correlates with bone strength. BMD testing is used to assess bone density and diagnose osteoporosis. The correlation between CT numbers and mechanical property estimated from cortical bone were found to be low (r2<0.2) and cancellous bone were found to be higher (r2>0.6). The specific relationship depending on the types of bone, that predict elastic module f...

Limited opportunity for movement and load-bearing exercise for conventionally caged laying hens leads to bone loss and increased susceptibility to osteoporosis, bone fractures, and cage layer fatigue, all of which compromise hen welfare and have negative consequences for production. The objective of this study was to compare bone mineral density (BMD) and strength measures of White Leghorns hou...