BACKGROUND The mechanism whereby bone activates resorptive behavior in osteoclasts, the cells that resorb bone, is unknown. It is known that α(v)β(3) ligands are important, because blockade of α(v)β(3) receptor signaling inhibits bone resorption, but this might be through inhibition of adhesion or migration rather than resorption itself. Nor is it known whether α(v)β(3) ligands are sufficient f...

Several inflammatory diseases have been associated with increased bone resorption and fracture rates and different studies supported the relation between inflammatory cytokines and osteoclast activity. The main factor required for osteoclast activation is the stimulation by receptor activator of nuclear factor kappa-B ligand (RANKL) expressed on osteoblasts. In this context, interleukin- (IL-) ...

Acute pericoronitis (AP) arises frequently in incompletely impacted mandibular third molars, but it remains unknown whether bone resorption in aging is associated with acute inflammation of the third molar. We conducted an experiment to compare the ratio of bone resorption to root length in the distal surface of the second molar (A), the proximal surface (B), and distal surface (C) in mesio-ang...

Statins have been postulated to affect bone metabolism. We investigated the effects of different doses of simvastatin (1, 5, 10, and 20 mg. kg(-1). d(-1)), atorvastatin (2.5 mg. kg(-1). d(-1)), and pravastatin (10 mg. kg(-1). d(-1)) administered orally for 12 weeks to intact female Sprague-Dawley rats and the effect of 20 mg. kg(-1). d(-1) simvastatin in sham-operated and ovariectomized rats on...

Surprisingly little is known about the factors released from bone during resorption and metabolic roles they play. This paper describes what we have learned bone, mainly through study of burn injuries, play in post-burn metabolism. From these studies, know that calcium, phosphorus, magnesium, along with transforming growth factor (TGF)-?, are following resorption. Additionally, studies mice Kar...

OBJECTIVE The aim of this study is to determine the relation of osteoporosis and body mass index to edentulous jaw bone resorption. MATERIAL AND METHODS Study included 48 postmenopausal totally edentulous female patients, aged 50 to 84 years (average age 69.73), with period of at least 2 years after last tooth extraction. Bone mineral density was determined in the femoral neck and the lumbar ...

Regulation of RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclast differentiation is of current interest in the development of antiresorptive agents. Osteoclasts are multinucleated cells that play a crucial role in bone resorption. In this study, we investigated the effects of N-methylpyrrolidone (NMP) on the regulation of RANKL-induced osteoclastogenesis. NMP inhibited RA...

Miljanka VUKSANOVIĆ Kliničko odeljenje za endokrinologiju, dijabetes i bolesti metabolizma Interna klinika Kliničko-bolnički centar „Zvezdara“ Dimitrija Tucovića 161 11000 Beograd Srbija [email protected] SUMMARY Bone is a living tissue, metabolically very active, with the level of turnover of about 10% per year. Bone remodeling is a well-balanced process of bone resorption, induced by osteoc...

To date, mesenchymal cells have only been associated with bone resorption indirectly, and it has been hypothesized that the degradation of bone is associated exclusively with specific functions of osteoclasts. Here we show, in aseptic prosthesis loosening, that aggressive fibroblasts at the bone surface actively contribute to bone resorption and that this is independent of osteoclasts. In two s...