The cement-bone interface plays an important role in load transfer between cemented implant systems and adjacent bone, but little is known about the micromechanical behavior of this interface following in vivo service. Small samples of postmortem-retrieved cement-bone specimens from cemented total hip replacements were prepared and mechanically loaded to determine the response to tensile and co...

BACKGROUND Intermittent administration of parathyroid hormone (PTH) leads to bone formation by increasing osteoblast numbers and activity levels. Animal studies have shown that intermittent PTH administration increases implant fixation in normal rats. The purpose of this study was to analyze the osseous incorporation of an implant in osteoporotic rats while treating them with intermittent PTH (...

Finite element has been used for more than four decades to study and evaluate the mechanical behaviour total joint replacements. In Huiskes seminal paper "Failed innovation in total hip replacement: diagnosis and proposals for a cure", finite element modelling was one of the potential cures to avoid poorly performing designs reaching the market place. The size and sophistication of models has i...

Medical procedures to address bone related injury are prevalent in the United States, with around 900,000 hospitalizations due to fractures and over 800,000 grafting procedures annually. Calcium phosphates (CPs) are particularly promising as bone substitute materials, due to their similarity to hydroxyapatite, the mineral component of bone. In addition to being non-toxic, they are biocompatible...

Although hip simulators for in vitro wear testing of prosthetic materials used in total hip arthroplasty (THA) have been available for a number of years, similar equipment has yet to appear for endurance testing of fixation in cemented THA, despite considerable evidence of late aseptic loosening as one of the most significant failure mechanisms in this type of replacements. An in vitro study of...

Studies of hypervitaminosis A in animals and anecdotal reports of accidental vitamin A poisoning in humans suggest impairment of bone remodeling and increased numbers of fractures. Because of the widespread use of high-dose vitamin A supplements which may produce subclinical hypervitaminosis associated with decreased bone mass and increased risk of fracture, we studied the relationship between ...

New materials that mimic natural bone properties, matching functional, mechanical, and biological properties have been continuously developed to rehabilitate defects. Desirably, ‘tissue engineering’ has a multidisciplinary ground uses the principles of life sciences engineering for replacements restore or replace tissue function whole organ. Nevertheless, grafting treatment numerous restriction...

INTRODUCTION: Tissue engineering and ex vivo gene therapy can be used synergically as a tool to regenerate bone that overcomes the problems of currently available bone replacements. Recently, in our lab a new source of mesenchymal stem cells (MSCs) has been found in the umbilical cord; Human Umbilical Cord Perivascular cells (HUCPVCs) provide an alternative to bone marrow derived MSCs. Due to t...

Glenoid component loosening is a commonly encountered complication of total shoulder replacements. Therefore, focus has been placed on glenoid fixation. Porous metal implants, which promote biological fixation through osteointegration, have provided an uncemented alternative to the traditional cemented implant. In this explantation study, the authors examined the bone ingrowth and ongrowth of a...