BACKGROUND In this study, the biocompatibility, stability and osteotransductivity of a new cement based on alpha-tricalcium phosphate (alpha-TCP) were investigated in a bone repair model using a rat model. METHODS The potential of alpha-TCP on bone repair was compared to autogenous bone grafting, and unfilled cavities were used as negative control. Surgical cavities were prepared and designat...

Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and os...

The establishment of a suitable animal model of repair of the rotator cuff is difficult since the presence of a true rotator cuff anatomically appears to be restricted almost exclusively to advanced primates. Our observational study describes the healing process after repair of the cuff in a primate model. Lesions were prepared and repaired in eight 'middle-aged' baboons. Two each were killed a...

BACKGROUND Rotator cuff tears are a common source of pain and disability, and poor healing after repair leads to high retear rates. Bone loss in the humeral head before and after repair has been associated with poor healing. The purpose of the current study was to mitigate bone loss near the repaired cuff and improve healing outcomes. METHODS Sclerostin antibody (Scl-Ab) treatment, previously...

Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic and an osteogenic gene. Stem cell-mediated osteogenesis in vitro, in addition to increased vascularization and bone repair by host cells in vivo, is enhanced using all systems while the use of the nanohydroxyapatite vector to deliver both genes markedly enhances bone healing.

A clinical case of bilateral cleft palate repair using previous tongue flap followed by Alveolar Bone Grafting(ABG). After pre-surgical orthodontics a surgical procedure whereby Flaps were reflected, nasalbeds prepared on both sides. cortico-cancellous bone 2 cm was harvested from iliac crest and grafted inclefts. Patient is kept follow up to monitor healing, postoperative results any post- ope...

Engineered Vascularized Flaps In article number 2008687, Shulamit Levenberg and co-workers fabricate composite neo-tissue flaps by combining polymeric matrices decellularized bone. These are perfused in vivo using hosts via a potent neo-vascular network. imaging is utilized to show how support long-term bone repair vascularization. This methodology may one day replace autologous tissue harvest ...

We hypothesized that reduced stem stiffness of orthopaedic implants contributes to a high risk of loosening, since interface stresses and relative motions may exceed a tolerable range. To study this hypothesis, three types of load-bearing implant with different stiffnesses were inserted into the tibia of the goat. Histological analysis was performed of bone repair after insertion of the implant...