INTRODUCTION: Iliac crest autograft is considered the gold standard graft material despite limitations in the quantity available and potential complications associated with harvesting procedure. These disadvantages have motivated clinicians and investigators to seek alternative graft materials to extend, enhance and/or substitute for autograft. Examples of such alternatives include: allografts,...

This study investigated the delivery of bone morphogenetic protein (BMP)4-secreting muscle-derived stem cells (MDSC-B4) capable of inducing bone formation in mice using collagen gel (CG), fibrin sealant (FS), and gelatin sponge carriers. After implanting these various cell-loaded scaffolds intramuscularly or into critical-size skull defects, we measured the extent of heterotopic ossification an...

The fabrication of the Guided Tissue Regeneration (GTR) membrane materials have become the key technique of the tissue engineering scaffold study. The cells adhere well on the fibers whose dimension is below their own so that the porous three dimension scaffold material can mimic the strueture of the natural extracellular matrix better and have the potential to be an ideal GTR membrane material...

The purpose of this study was to evaluate a thin gelatin hydrogel membrane containing β-tricalcium phosphate (G-TCP) for use in guided bone regeneration, a technique that we developed. G-TCP membranes were fabricated from gelatin and β-TCP powder, freezedried, and cross-linked by heating. The resulting G-TCP membranes were as thin as collagen membranes, with high mechanical integrity. Prolifera...

background: engineering new bone tissue with cells and a synthetic extracellular matrix represents a new approach for the regeneration of mineralized tissues compared with the transplantation of bone (autografts or allografts). methods: in this study, to mimic the mineral and organic component of natural bone, hydroxapatite (ha) and gelatin (gel) composite scaffolds were prepared. the raw mater...

Gelatin is a soluble protein that acts as gelling agent and commonly used an ingredient in both food non-food production. Since bone composed of collagen fibers, it can be raw material for gelatin Beef waste product rarely used. Sodium hydroxide (NaOH) processing the production type B because remove fats oils. The purpose this study was to investigate effects 2%, 3%, 4%, 5%, 6%NaOH concentratio...

introduction: the aim of this in vivo study was to determine the effect of demineralized bone matrix (dbm) on alveolar bone repair in type i diabetic rats. materials and methods: this study was carried out on 40 adult (8 weeks-old) albino rats with an average weight of 200-250 grams. the animals were divided into four groups (n=10) as follows: group 1 nondiabetic rats, group 2, 3 and 4 were dia...