A 70-year-old woman with renovascular hypertension presented with 8 weeks of worsening chest pain, back and leg pain, dyspnea, and fatigue. She had a faint petechial rash on the abdomen and thighs. Complete blood count showed leukocytosis (26.6 109/L), anemia (100 g/L), and thrombocytopenia (114 109/L). Manual differential count revealed 5% myeloblasts, 2% myelocytes, 1% metamyelocytes, 1% eosi...

A 68-year-old man presented to us with pancytopenia, erythroderma, and multiple lymphadenopathies. Lymph node biopsy led to the diagnosis of peripheral T-Cell lymphoma-not otherwise specified (PTCL-NOS). Immunostaining of the lymph node biopsy specimens for cytokines revealed that the tumor cells were positive for plated-derived growth factor (PDGF), basic fibroblast growth factor (b-FGF), vasc...

INTRODUCTION Sarcoidosis is an inflammatory disorder characterized by the presence of non-caseating granulomas in affected organs. The presence of CD4-positive T lymphocytes and macrophages in affected organs suggests an ongoing immune response. Systemic corticosteroids remain the mainstay of treatment, but therapy is often limited by adverse effects. This is the first report of the use of adal...

To cite: Khoshnaw NSH, Muhealdeen DN. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014203891 DESCRIPTION A 58-year-old Kurdish woman with a history of diabetes, presented to our clinic with fever and rigour for 2 week’s duration, associated with diffuse bone pain and weight loss. Laboratory work showed pancytopenia with haemoglobin 107 g/L, white cell count 3....

PURPOSE To investigate the function and expression of Toll-like receptors (TLR) in bone marrow cells of myelodysplastic syndrome (MDS) patients and to examine their involvement in the apoptotic phenomenon characterizing MDS hematopoiesis. EXPERIMENTAL DESIGN TLR mRNA and protein expression was investigated in bone marrow cell populations of MDS patients and controls. TLR-4 ability to recogniz...

In order to study the normal hematopoiesis, cellular components and myeloid/erythroid (M/E) ratio in the bone marrow of the pheasant (Phasianus colchicus), bone marrow samples were collected from the proximal tibiotarsus bone of 16 clinically healthy adult pheasant. The bone marrow smears were stained using the Giemsa stain. The results indicated that the development and formation of b...

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Bone marrow necrosis (BMN) is a rare clinicopathologic entity caused by hypoxemia after failure of the microcirculation, which frequently manifests with bone pain, fever, and peripheral cytopenia. In most reported cases of BMN resulting from miliary tuberculosis (TB), the presence of marrow granulomas, pulmonary infiltrates and/or extrapulmonary involvement is common. We report a female patient...

Background: Pancytopenia is a manifestation of a wide range of disorders. The main prognostic factor for predicting outcome and response to treatment is based on the underlying cause. To detect the root cause of this problem, depending on other accompanied signs or symptoms, the need for bone marrow examination and other advanced work ups is different at least at the practical level. This study...