Angiogenesis inhibitor TNP-470, 6-O-(A'-chloroacetyl-carbamoyl)-fumagillol, semisynthetic analogue of fumagillin, has strong inhibitory activ ities against in vivo tumor growth and metastasis in a wide variety of tumors. However, it is still unknown whether this agent inhibits bone metastasis. We examined the effects of TNP-470 in a bone metastasis model in nude mice in which intracardiac injec...

acute myeloid leukemia (aml-m7) is a type of pediatric aml accounting for 3–10% of primary childhood aml and children may present with a broad variety of symptoms including low-grade fever, diarrhea, easy bruising, failure to gain weight and life-threatening conditions. we report a rare case of aml .a 26-month-old boy who presented with weakness and fatigue. he was diagnosed as a case of amlm-7...

background: anti-hla-antibodies are known to affect the allograft survival in transplant recipient patients. objective: the aim of this study was to evaluate the association between anti-hla antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (dbmi). methods: between june 2006 and may 2007, forty living unrelated donor kidney tra...

Rhabdomyosarcoma caused bone marrow metastasis cases are among the rarest reported in literature. Similar to literature, clinical presentation of our patient mimicked acute leukemia, and leukoerythroblastosis peripheral smear test cytopenia hemogram raised suspicion hematological malignancy initially.1,2 The diagnosis made by immunohistochemical staining biopsy. primary tumor field could not be...

Bone is the most frequent site of metastasis in prostate cancer and patients with bone metastases are deemed incurable. Targeting prostate cancer cells that disseminated to the bone marrow before surgery and before metastatic outgrowth may therefore prevent lethal metastasis. This prompted us to directly analyze the transcriptome of disseminated cancer cells (DCC) isolated from patients with no...

Human prostate cancer often metastasizes to bone, but the biological basis for such site-specific tropism remains largely unresolved. Recent work led us to hypothesize that this tropism may reflect pathogenic interactions between RAGE, a cell surface receptor expressed on malignant cells in advanced prostate cancer, and proteinase 3 (PR3), a serine protease present in inflammatory neutrophils a...

OBJECTIVE To determine the value of 18F-FDG PET/CT in detection of bone marrow (BM) metastasis in breast cancer which is considered an early stage of bone metastasis. PATIENTS AND METHODS Retrospectively, breast cancer patients with bone metastasis were included. BM metastasis was considered if the lesion was PET positive/CT occult while bone metastasis was considered if the lesion was PET po...

Bone and lung metastases are responsible for the majority of deaths in patients with breast cancer. Following treatment of the primary cancer, emotional and psychosocial factors within this population precipitate time to recurrence and death, however the underlying mechanism(s) remain unclear. Using a mouse model of bone metastasis, we provide experimental evidence that activation of the sympat...

Bonemetastasis greatly deteriorates the quality of life in patientswith cancer. Althoughmechanisms have been widely investigated, the relationship between cancer bone metastasis and antitumor immunity in the host has been much less studied. Here, we report a novel mechanism of bone metastasis mediated by FSTL1, a follistatinlike glycoprotein secreted by Snailþ tumor cells, whichmetastasize freq...

Skeletal metastases are complications of epithelial cancers, among which breast, prostate and lung carcinomas are the most osteotropic. In primary tumours, a subset of cancer cells undergoes epithelial-mesenchymal transition, acquires mobility to migrate into the surrounding stroma and seeds at distant sites to grow. The specific development of bone metastasis requires the recruitment of circul...