Background: Recent clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to compare effect of intravenous injection of bone marrow mesenchymal stem cells (BMSC) and bone marrow hematopoietic stem cell mobilization, induced by granulocyte colony stimulating factor (G-CSF), in rats with a cortical compact device. Methods: Forty adult male Wistar rats w...

conclusions although the aforementioned challenges must still be addressed, the potential of wjmscs in skin regenerative clinical treatments is promising. results similar to bone marrow mscs, wjmscs express major histocompatibility complex (mhc) class i molecules. evidence acquisition according to research conducted by various researchers, wharton’s jelly mesenchymal stem cells (wjmscs) have se...

INTRODUCTION Mesenchymal stem cells (MSCs) are defined as cells that can differentiate into multiple mesenchymal lineage cells. MSCs were obtained from various sources; bone marrow, umbilical cord blood, adipose tissue and synovium etc. It has been reported that MSCs isolated from the bone marrow showed variation in size, morphology and level of alkaline phosphatase activity among clones isolat...

objective(s):sea cucumber derived bioactive compound is considered efficient in treatment of bone disorders. this study was performed   to evaluate the effect of this extract on differentiation of rat bone marrow mesenchymal stem cells (rbmmsc) into osteogenic lineage. materials and methods: isolated rbmmsc were grown in dmem supplemented with 10% fbs. the cells were exposed to different concen...

AIM to speed up transdifferentiation of bone marrow-derived stem cells into cardiomyocyte in vitro by inducing dedifferentiation of bone marrow-derived mesenchymal stem cell, before induction by 5-aza-2'-deoxycytidine into cardiomyocyte. METHODS two-three months old 2.5 kg weight adult male New Zealanad Rabbits were anesthezied with ether, thigh bones were excised, and bone marrow cells were ...

Subcutaneous adipose tissue has recently been attracting attention as a new cell source for regenerative medicine, replacing bone marrow. Among fibroblast-like cells, termed adipose stromal cells, stromalvascular cells, and preadipocytes, cells with potency to differentiate into not only adipocytes and blood vessels but also various lineages are present [1], and they are termed adipose-derived ...

background infertility is a serious social problem in advanced nations, with male factor in half of all cases of infertility. this study was conducted to determine the regenerative effect of bone marrow-derived stem cells in spermatogenesis of infertile hamster. methods twelve adult male hamsters were equally divided into azoospermic and control groups. busulfan was intraperitoneally used for i...

Objective(s):Sea cucumber derived bioactive compound is considered efficient in treatment of bone disorders. This study was performed   to evaluate the effect of this extract on differentiation of rat bone marrow mesenchymal stem cells (rBMMSc) into osteogenic lineage. Materials and Methods: Isolated rBMMSc were grown in DMEM supplemented with 10% FBS. The cells were exposed to different concen...

the stem cells can be considered as the miracle of creation, because, they are a major reservoir of the bioactive factors, molecules and cells. these reservoir cells play a major role in development and growth of the tissues and organs. regardless of the differences in differentiation capacity of embryonic and adult stem cells, both the cells are rich sources of stem cells with therapeutic appl...