Objective: This study aimed to investigate the combined effects of caffeine and Alpha Lipoic Acid (ALA) on oxidative stress, due chronic hyperglycemia, in a model diabetic rats induced with streptozotocin (STZ) (in silico vivo approaches). Material Methods: In investigated interaction between ALA against insulin receptors enzymes Glutathione Peroksidase-1 (GPx-1), molecular docking. Male, Wista...

First-principles calculations were employed to elucidate the origin of adsorption-induced surface stresses in alkanethiolate self-assembled monolayers on an Au(111) surface. Our results suggest a mechanism that accounts for the huge relief of the tensile stress compared to the bare surface in terms of a local rearrangement of surface Au atoms accompanying charge removal from the surface towards...

Discrete granular model in a low stress state as well as retaining homogeneous porosity is the premise and foundation to obtain good results with particle flow method. AutoCAD is used as the processing software in which Polyline is used to render the scope of modeling and the 3dface is used to set delivery area of particles, then the improved expansion-particle method is prepared for generating...

Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...

introduction: introduction: few studies have investigated the distribution of stress around implants. in this study the distribution of stress in bones around implants was investigated in five overdenture (od) treatment designs including od-1, od-2, od-3, od-4 and od-5. materials and methods: the catia modeling software was used in order to simulate the tooth/implant model and bone. first, the ...

Modified ANO-RCC basis sets are used to determine twelve molecular graphs of the Ehrenfest force for H2, CH4, CH2O, CH3NO, C2H2, C2H4, C3H3NO, N4H4, H2O, (H2O)2, (H2O)4 and (H2O)6. The molecular graphs include all types of topological critical points and a mix of bonding types is chosen to include sigma-, π- and hydrogen-bonding. We then compare a wide range of point properties: charge density,...

Networks of aggregated colloidal particles are solidlike and can sustain an applied shear stress while exhibiting little or no creep; however, ultimately they will catastrophically fail. We show that the time delay for this yielding decreases in two distinct exponential regimes with applied stress. This behavior is universal and found for a variety of colloidal gel systems. We present a bond-ru...

OBJECTIVES Bond strength between adhesive systems and the tooth structure is influenced by a large number of variables, which makes the comparison among studies virtually impossible. Also, failure often times propagates into the dental substrate or the composite, deeming the results questionable at best. In spite of the increased popularity gained by micro-tensile and micro-shear tests, in vitr...

We carried out a residual stress distribution analysis in a APS TBC throughout the depth of the coatings. The samples were heat treated at 1150 °C for 190 h and the data analysis used image based modelling based on the real 3D images measured by Computed Tomography (CT). The stress distribution in several 2D slices from the 3D model is included in this paper as well as the stress distribution a...

In dynamic force spectroscopy, a (bio-)molecular complex is subjected to a steadily increasing force until the chemical bond breaks. Repeating the same experiment many times results in a broad distribution of rupture forces, whose quantitative interpretation represents a formidable theoretical challenge. In this study we address the situation that more than a single molecular bond is involved i...