Boron neutron capture therapy (BNCT) is successful when there is a sufficient (10)B concentration in tumor cells. In melanoma, (10)B-para-boronophenylalanine (BPA) accumulation is proportional to melanin-producing activity. This study was done to confirm enhancement of the tumor-suppressive effect of BNCT on amelanotic melanoma by intratumoral injection of the tyrosinase gene. D178 or FF amelan...

The neutron irradiation system for boron neutron capture therapy (BNCT) using compact accelerators installed at hospitals was mainly investigated for the usage of direct neutrons from near-threshold Li(p,n)Be, and moderated neutrons from 2.5 MeV Li(p,n)Be reactions and other reactions. This kind of system can supply the medical doctors and patients with convenience to carry out BNCT in hospital...

BACKGROUND Boron neutron capture therapy (BNCT) is a selective radiotherapy, being effective for the treatment of even advanced malignancies in head and neck regions as well as brain tumors and skin melanomas. To clarify the role of p53 gene, the effect of BNCT on oral squamous cell carcinoma (SCC) cells showing either wild- (SAS/neo) or mutant-type (SAS/mp53) p53 was examined. METHODS Cells ...

BACKGROUND Radiologic response of brain tumors is traditionally assessed according to the Macdonald criteria 10 weeks from the start of therapy. Because glioblastoma (GB) responds in days rather than weeks after boron neutron capture therapy (BNCT) that is a form of tumor-selective particle radiation, it is inconvenient to use the Macdonald criteria to assess the therapeutic efficacy of BNCT by...

O Centro de Arte Contemporânea (CAC) funcionou entre 1976 e 1980 no Museu Nacional Soares dos Reis (MNSR), Porto, com vista à exposição, estudo divulgação arte contemporânea. Este artigo tem como objetivo analisar a parceria institucional estabelecida o CAC MNSR durante esses quatro anos. Para tal, torna-se importante contextualizar criação do partir da perspetiva ausência um museu moderna capa...