Bloom's syndrome (BS) cells display a characteristic genomic instability, notably an elevated frequency of sister-chromatid exchange. Replicating DNA in cultured BS cells was labeled with [3H]thymidine using several time schedules. Separation of DNA in agarose gels showed high molecular weight DNA and three classes of DNA replication intermediates: 20-kilobase DNA, 10-kilobase DNA, and Okazaki ...

1. S.L. Bloom, The hyperprojective hierarchy, Notices of the AMS, Vol. 15(1968), 343. 2. S.L. Bloom, Theories of kind W, Notices of the AMS, 16(1969), 507. 3. S.L. Bloom, D. Brown, Classical abstract logics I, Notices of the AMS, 18(1971), 827. 4. S.L. Bloom, D. Brown, Classical abstract logics II, Notices of the AMS, 18(1971), 968. 5. S.L. Bloom, R. Suszko, D. Brown, Structurality, substitutio...

Bloom syndrome, characterized by a predisposition to cancer, is caused by mutation of the RecQ DNA helicase gene BLM. The precise function of BLM remains unclear. Previous research suggested that Drosophila BLM functions in the repair of DNA double-strand breaks. Most double-strand breaks in flies are repaired by homologous recombination through the synthesis-dependent strand-annealing pathway....

Based on its in vitro unwinding activity on G-quadruplex (G4) DNA, the Bloom syndrome-associated helicase BLM is proposed to participate in telomere replication by aiding fork progression through G-rich telomeric DNA. Single molecule analysis of replicated DNA (SMARD) was used to determine the contribution of BLM helicase to telomere replication. In BLM-deficient cells, replication forks initia...

Introduction : This study was conducted among interns in medical college undergoing BLS training and who were previously not familiar with the BLS training skills. The main objective of this study was to assess the effectiveness of BLS training programme in improving cogitative skills of interns in medical college. Methodology : The study population included 91 intern medical students who were ...