the purpose of this study was to investigate the status and epidemiology of intestinal parasites in iran. the information was driven from an extensive health survey which was done by the ministry of health and medical education, deputy of research affairs in 1990-92. sampling fraction was 1 per 1000 of individuals aged between 2 and 69, the sampling method was cluster sampling and each cluster ...

Transmission of a Babesia species to susceptible cattle by Rhipicephalus evertsi evertsi ticks picked off a sable which died of acute babesiosis is described. The parasite was initially isolated by feeding R. e. evertsi ticks on a susceptible, splenectomised bovine which developed parasitaemia. Blood stabilate from the parasitaemic bovine produced a fatal babesiosis in a spleen--intact bovine. ...

Malaria is a highly prevalent disease caused by infection by Plasmodium spp., which infect hepatocytes and erythrocytes. Blood-stage infections cause devastating symptoms and can persist for years. Antibodies and CD4(+) T cells are thought to protect against blood-stage infections. However, there has been considerable difficulty in developing an efficacious malaria vaccine, highlighting our inc...

OVERVIEW Hepatozoonosis of domestic cats has been reported in several countries, mainly as a subclinical infection. DISEASE AGENT Infection has been described mostly in areas where canine infection is present and, in recent years, Hepatozoon felis has been identified as a distinct species by molecular techniques. The vector for feline hepatozoonosis remains unknown and the pathogenesis has no...

Malaria is a disease activated by type of microscopic parasite transmitted from infected female mosquito bites to humans. fatal that endemic in many regions the world. Quick diagnosis this will be very valuable for patients, as traditional methods require tedious work its detection. Recently, some automated have been proposed exploit hand-crafted feature extraction techniques however, their acc...

The influence of parasite genetic factors on immune responses and development of severe pathology of malaria is largely unknown. In this study, we performed genome-wide transcriptomic profiling of mouse whole blood during blood-stage infections of two strains of the rodent malaria parasite Plasmodium chabaudi that differ in virulence. We identified several transcriptomic signatures associated w...

Survival and virulence of the human malaria parasite Plasmodium falciparum during the blood stage of infection critically depend on extensive host cell refurbishments mediated through export of numerous parasite proteins into the host cell. The parasite-derived membranous structures called Maurer's clefts (MC) play an important role in protein trafficking from the parasite to the red blood cell...

OBJECTIVES This study describes parasite kinetics in the blood of visceral leishmaniasis patients treated with liposomal amphotericin B (L-AmB) or a preformed fat emulsion of amphotericin B (ApL) using real-time quantitative PCR (qPCR). METHODS Forty-six patients were treated with a single dose (15 mg/kg of body weight) of either L-AmB (n = 13) or ApL (n = 33). qPCR was used to estimate paras...

The ubiquitin-proteasome system (UPS) is a potential pathway for therapeutic intervention for pathogens such as Plasmodium, the causative agent of malaria. However, due to the essential nature of this proteolytic pathway, proteasome inhibitors must avoid inhibition of the host enzyme complex to prevent toxic side effects. The Plasmodium proteasome is poorly characterized, making rational design...