Myeloid cells comprise a heterogeneous population of cells that include granulocytes and monocytes. Recent data reveals a complex role of myeloid cells as mediators of tumor progression and tumor induced immunosuppression. Myeloid-derived suppressor cells (MDSCs) have been extensively studied in mouse models and are thought to be actively recruited to the tumor and suppress immunity through mul...

objectives : platelet preparations are commonly used to enhance bone and soft tissue regeneration. considering the existing controversies on the efficacy of platelet products for tissue regeneration, more in vitro studies are required. the aim of the present study was to compare the in vitro effects of plasma rich in growth factors (prgf) and platelet-rich fibrin (prf) on proliferation and viab...

Peripheral blood lymphocytes from 23 patients with active systemic lupus erythematosus (SLE) were serially studied. Changes in bone marrow-derived lymphocytes (B cells), as measured by surface Ig receptors and C3 receptors, and in thymus-derived cells (T cells) measured by rabbit T-cell-specific antiserum and E-binding techniques, were correlated with fluctuations in clinical disease activity a...

background: dendritic cells (dcs), as the managers of the immune response, have a crucial role in forming the direction and nature of the immune response. some compounds such as 1,25-dihydroxycholecalciferol affect the function of dcs and can be used to shift the immune functions toward favorite directions. the aim of this study was to investigate the in vivo effects of 1, 25- dihydroxycholecal...

The purpose of this study was to characterize the cell surface proteome of native compared to cultured equine retinal pigment epithelium (RPE) cells. The RPE plays an essential role in visual function and represents the outer blood-retinal barrier. We are investigating immunopathomechanisms of equine recurrent uveitis, an autoimmune inflammatory disease in horses leading to breakdown of the out...

A number of cell surface markers are expressed on resting peripheral blood (PB) T cells (1). However, there are a number of surface markers that are expressed only in low proportions or not at all on resting T cells, but that are clearly expressed in varying proportions on activated T cells. Among these markers of activated T cells, the receptors for the Fc portion of IgG (FcyR) are on small fr...

Peripheral blood T cells were immortalized in vitro by introduction of the Taxl gene of human T-cell leukemia virus type 1 (HTLV-1) with a retroviral vector and were characterized for transformation-associated markers. Long-term observation showed that these Taxl-immortalized T cells eventually exhibited very similar features that were characteristic of HTLV-1 -immortalized T cells, ie, increas...