نتایج جستجو برای: blast cell count

تعداد نتایج: 1793958  

Journal: :Blood 1988
A G Leary K Ikebuchi Y Hirai G G Wong Y C Yang S C Clark M Ogawa

Currently available evidence suggests that in the steady state, the majority of hematopoietic stem cells are dormant in cell cycle and reside in the so-called G0 period. Studies in our laboratory indicated that once a stem cell leaves G0, its subsequent proliferation requires the presence of interleukin-3 (IL-3). Recently it was reported that interleukin-1 (IL-1) may stimulate stem cells to bec...

2004
Richard M. Stone Daniel J. DeAngelo Virginia Klimek Ilene Galinsky Eli Estey Stephen D. Nimer Wilson Grandin David Lebwohl Yanfeng Wang Pamela Cohen Edward A. Fox Donna Neuberg Jennifer Clark D. Gary Gilliland James D. Griffin

Leukemic cells from 30% of patients with acute myeloid leukemia (AML) have an activating mutation in the FLT3 (fms-like tyrosine kinase) gene, which represents a target for drug therapy. We treated 20 patients, each with mutant FLT3 relapsed/ refractory AML or high-grade myelodysplastic syndrome and not believed to be candidates for chemotherapy, with an FLT3 tyrosine kinase inhibitor, PKC412 (...

2017
Jenna B Bhattacharya Richa Gupta Amit Samadhiya

s) 2008;112(Suppl);abst 2694. 11. Jensen PD, Heickendorff L, Pedersen B, et al. The effect of iron chelation on haemopoiesis in MDS patients with transfusional iron overload. Br J Haematol 1996;94:288-99. 12. Glickstein H, Nick H, Cabantchik ZI. Susceptibility of endocrine, cardiac, and macrophage cell lines to iron-mediated oxidative damage and the cytoprotective effect of the orally active ch...

1998
Giovanni Barosi Achille Ambrosetti Antonietta Centra Antonietta Falcone Carlo Finelli Paolo Foa Alberto Grossi Roberta Guarnone Serena Rupoli Luigiana Luciano Maria C. Petti Enrico Pogliani Domenico Russo Marco Ruggeri Silvana Quaglini

An unexpectedly high incidence of blast transformation after splenectomy has been reported in patients with myelofibrosis with myeloid metaplasia. However, whether this was associated with spleen removal after adjustment for risk factors was not determined. We conducted a multicenter historical cohort study of patients with myelofibrosis with myeloid metaplasia diagnosed from January 1970 throu...

Journal: :Blood 1998
G Barosi A Ambrosetti A Centra A Falcone C Finelli P Foa A Grossi R Guarnone S Rupoli L Luciano M C Petti E Pogliani D Russo M Ruggeri S Quaglini

An unexpectedly high incidence of blast transformation after splenectomy has been reported in patients with myelofibrosis with myeloid metaplasia. However, whether this was associated with spleen removal after adjustment for risk factors was not determined. We conducted a multicenter historical cohort study of patients with myelofibrosis with myeloid metaplasia diagnosed from January 1970 throu...

Journal: :The European Research Journal 2023

Objectives: Our aim in this study is to investigate the effect of fibrosis at diagnosis on treatment and survival childhood acute lymphoblastic leukemia (ALL). Methods: This retrospective. We evaluated relationship between patients' age, white blood cell count diagnosis, morphological blast percentage flow cytometric day 15th 33th, absolute peripheral smear 8th, degree bone marrow biopsy 36 ped...

2010
Emily Payne Ahmed Salamt Philip Connor

A three-week-old boy with Down syndrome presented with poor feeding and jaundice. He had been born at term by normal delivery at home. The pregnancy had been uneventful and the mother had declined antenatal testing so the diagnosis of Down syndrome was made in the postnatal period. The infant required oxygen at birth and was admitted to the neonatal unit for a few days after birth. He started t...

Journal: :Voprosy gematologii/onkologii i immunopatologii v pediatrii 2021

The purpose of this work was evaluation prognostic significance 11q23/KMT2A rearrangements in infants (aged under 365 days) with B-cell precursor acute lymphoblastic leukemia (ALL) enrolled Russian-Belarus multicenter trial MLLBaby. This study is supported by the Independent Ethics Committee and approved Academic Council Research Institute Medical Cell Technologies (Ekaterinburg). Various were ...

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