Most bladder tumors have complex genomes characterized by a high mutation burden as well as frequent copy number alterations and chromosomal rearrangements. Alterations in DNA repair pathways-including the double-strand break (DSB) and nucleotide excision repair (NER) pathways-are present in bladder tumors and may contribute to genomic instability and drive the tumor phenotype. DNA damaging suc...

background: recognition of the predisposing factors of bladder cancer is very important and provides possible prevention measures. the aim of this study was to investigate the types, distribution of bladder tumors and their relationship with opium consumption and smoking in patients who referred to shahid beheshti hospital, babol, iran. methods: in this case-control study, all patients diagnose...

Bladder cancer is a significant cause of morbidity and mortality today. Histopathological staging [1,2] and adequate tumor clearance is critical in prognosticating and assessing adequacy of treatment. Obtaining detrusor muscles during transurethral resection of bladder tumours (TURBT) is vital for cancer staging [3]. Deep cold-cup biopsy at transurethral resection of bladder tumors (TURBT) is n...

Bladder cancer is a significant cause of morbidity and mortality today. Histopathological staging [1,2] and adequate tumor clearance is critical in prognosticating and assessing adequacy of treatment. Obtaining detrusor muscles during transurethral resection of bladder tumours (TURBT) is vital for cancer staging [3]. Deep cold-cup biopsy at transurethral resection of bladder tumors (TURBT) is n...

PURPOSE To investigate and compare the expression of OCT4B1 between tumor and non-tumor bladder tissues. MATERIALS AND METHODS We investigated the expression of OCT4B1 in 30 tumor and non-tumor surgical specimens of the bladder, using the TaqMan real-time polymerase chain reaction approach and by carefully designing primers and probes specific for the amplification of the variant. RESULTS M...

Bladder-sparing options are being developed for muscle-invasive bladder cancer in place of radical cystectomy, including the combination of chemotherapy and radiation therapy. We reasoned that improving the radiotherapy component of chemoradiation could improve the control of locally advanced disease. Previously, we showed that gold nanoparticles (AuNPs) are potent enhancers of radiation therap...

Urinary bladder paraganglioma is a rare neuroendocrine tumor and nonfunctional bladder paraganglioma is extremely rare and difficult to diagnose due to their non-secreting nature. We report a rare female case of nonfunctional bladder paraganglioma with detailed clinicopathological data and follow-up information. The patient presented with supra-pubic pain. Computed tomography (CT) revealed a 11...

OBJECTIVE To determine the diagnostic accuracy of high-resolution MR imaging done at 1.5T in distinguishing bladder-restricted tumor from non-bladder-restricted tumor and compare the mean short axis dimension of metastatic pelvic lymph nodes with benign pelvic lymph nodes. STUDY DESIGN Analytical study. PLACE AND DURATION OF STUDY Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, f...

miRNAs are involved in cancer development and progression, acting as tumor suppressors or oncogenes. In this study, miRNA profiling was conducted on 10 paired bladder cancer tissues using 20 GeneChip miRNA Array, and 10 differentially expressed miRNAs were identified in bladder cancer and adjacent noncancerous tissues of any disease stage/grade. After being validated on expanded cohort of 67 pa...