Background: Bladder dysfunction is very common in patients with multiple sclerosis (MS), affecting up to 6090% of patients with MS at any stage during the course of their disease. Bladder dysfunction in MS patients can be classified into (a) Detrusor hyperreflexia or overactivity and (b) Detrusor external sphincter dyssynergia (DESD). Aim of the study: To evaluate the effect of botulinum toxin ...

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Urinary bladder cystitis occurs in patients receiving radiation therapy for pelvic tumors. Radiation-induced formation of superoxide radicals is believed to damage the urothelium, exposing the underlying bladder smooth muscle to urine, culminating in nerve irritation and muscle dysfunction. We tested whether overexpression of MnSOD could decrease superoxide levels and protect the bladder from r...

Neurogenic bladder (NB) or neurogenic lower urinary tract dysfunction (NLUTD), a dysfunction of the urinary bladder and urethra due to disease of the central nervous system or peripheral nerves, is a major global medical and social problem. Numerous nervous system abnormalities, such as: stroke, Alzheimer's and Parkinson's diseases, traumatic spinal cord injury, spinal cord tumors, congenital s...

BACKGROUND Despite recent efforts to educate multiple sclerosis (MS) health-care providers about the importance of pelvic floor disorders (urinary, bowel, and sexual dysfunction), no data are currently available to assess outcomes of these efforts in terms of patient satisfaction. METHODS As part of the fall 2010 North American Research Committee on Multiple Sclerosis survey, we conducted a p...

Bladder dysfunction is a relatively common urodynamic finding post radical prostatectomy (RP). It can be the sole cause of post prostatectomy incontinence (PPI) or may be found in association with stress urinary incontinence (SUI). The aim of this review is to provide a comprehensive review of the diagnosis and different treatments of post RP bladder dysfunction. A comprehensive literature revi...

BACKGROUND Posterior urethral valves (PUV) may cause subtle to severe obstruction of the urethra, resulting in a broad clinical spectrum. PUV are the most common cause of chronic renal disease in boys. Our purpose was to report the incidences of kidney and bladder dysfunction in boys treated with endoscopic valve resection for PUV. METHODOLOGY We searched MEDLINE and EMBASE databases until 1s...

TO THE EDITOR: Ketamine-induced cystitis was first reported by Shahani et al. in 2007 (6). Clinical presentations of this entity is characterized by lower urinary tract symptoms (LUTS), such as frequency, urgency, gross hematuria, and bladder pain (2, 6). The underlying mechanisms are still unelucidated in ketamine-induced cystitis, and the approaches to therapy include cessation of ketamine, m...

We report one institution's six-year experience using botulinum toxin A (BONT-A) in the bladder and urethra in 110 patients for a variety of lower urinary tract dysfunction. 110 patients (age 19-82) were injected with BONT-A into the bladder (n=42) or urethra (n=68), 35 M, 75 F. Voiding dysfunction included: neurogenic detrusor overactivity and/or detrusor sphincter dyssynergia, overactive blad...

OBJECTIVES To evaluate the efficacy of botulinum toxin A in the treatment of children with detrusor hyperreflexia caused by myelomeningocele and the effects of this treatment on neuropathic bladder and bowel dysfunction. METHODS In a prospective study, 26 children with myelomeningocele (20 boys and 6 girls, mean age 6.9 years) were included. All patients had been nonresponders to medical trea...