OBJECTIVE To develop recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP). METHODS We conducted a systematic review to synthesize the evidence for the benefits and harms of GIOP prevention and treatment options. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to rate the quality of evidence. We used a group conse...

BACKGROUND Preexisting gastrointestinal (GI) events may deter the use of pharmacologic treatment in patients diagnosed with osteoporosis (OP). The objective of this study was to examine the association between preexisting GI events and OP pharmacotherapy initiation among women diagnosed with OP. METHODS The study utilized claims data from a large US managed care database to identify women age...

A 77-year-old Japanese woman with cervical dystonia was admitted to our institution for steroid therapy acute hepatitis secondary autoimmune hepatitis. We prescribed oral bisphosphonates prevent steroid-induced osteoporosis. Six days after the first dose of bisphosphonate, patient complained pharyngeal and back pain. Upper gastrointestinal endoscopy revealed an ulcer in esophagus (Figure A). Co...

PURPOSE To assess the risk and time course of oral bisphosphonate-induced osteonecrosis of the jaws. MATERIALS AND METHODS Detailed data from 30 consecutive cases were compared with 116 cases due to intravenous aminobisphosphonates. RESULTS Results in part noted a higher incidence related to alendronate (Fosamax; Merck, Whitehouse Station, NJ), a 94.7% predilection for the posterior mandibl...

Meta-CASE tools are used to generate CASE tools; KOGGE is such a meta-CASE system. Two of KOGGE's main objectives are adaptability and exibility which address the growing need for problem speciic solutions. As an example it is shown how a CASE tool for the object-oriented method BON BONsai was constructed using KOGGE.

The case is reported of a 77 year old lady admitted with sepsis, hypotension, lactic acidosis and acute kidney injury from an uncertain origin. She had a background of myeloma which had been treated 18 months earlier and had been continued on the bisphosphonate clodronate. Sepsis was empirically treated with gentamicin, benzyl-penicillin and metronidazole. On day 4 of admission she was noted to...

Bisphosphonates are a common treatment for osteoporosis. Osteonecrosis of the jaw has been associated with the use of bisphosphonates, usually when they have been used parenterally to treat malignancies. Cases associated with oral bisphosphonate as a treatment for osteoporosis are less frequent. We describe two patients exhibiting the clinical manifestations of bisphosphonate-associated osteone...

Despite the increasing number of cases of osteonecrosis of the jaws related to bisphosphonate therapy described in the literature there is a paucity of evidence-based treatment for the condition. In this second article on bisphosphonate-related jaw complications we discuss the different treatment strategies for the condition, review current literature, particularly in relation to the recommenda...

Meta-CASE tools are used to generate CASE tools; KOGGE is such a meta-CASE system. Two of KOGGE's main objectives are adaptability and exibility which address the growing need for problem speciic solutions. As an example it is shown how a CASE tool for the object-oriented method BON { BONsai { was constructed using KOGGE.

BACKGROUND Bisphosphonate-related osteonecrosis is an infrequent but potentially serious complication. Its treatment remains complex, and in some cases can be mutilating. Prevention, a correct diagnosis and opportune management are crucial. MATERIAL AND METHODS A cross-sectional study was made, interviewing 410 dentists with the aim of assessing their knowledge of the subject. RESULTS Pract...