OBJECTIVES To examine the feasibility of collecting course of illness data from patients with bipolar I and II disorder, using weekly text-messaged mood ratings, and to examine the time trajectory of symptom ratings based on this method of self-report. METHODS A total of 62 patients with bipolar I (n = 47) or II (n = 15) disorder provided mood data in response to weekly cell phone text messag...

Some of the most challenging facets of bipolar disorder involve the management of its depressive symptoms. This article will focus on the pharmacologic management of this phase of bipolar disorder, describing the evidence base for controlled studies, emerging treatments, and expert recommendations. An unmet need exists for acute and maintenance treatments that target depressive symptoms in bipo...

OBJECTIVE Previous studies attempting to identify neuropathological alterations in the hippocampus in bipolar disorder have been inconclusive. The objective of this study was to determine if the concentration of N-acetylaspartate, a neuronal and axonal marker, was lower in subjects with familial bipolar I disorder than in healthy comparison subjects, suggesting possible neuronal loss, neuronal ...

BACKGROUND Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research. AIMS To use genome-wide genetic association data to explore the relative genet...

I address early onset Bipolar Mood Disorder, exploring the ways in which the disorder manifests in the lives of children. Complications in current and past literature are clarified, and the dearth of substantive research into the area is noted. I clarify associated risk factors specific to paediatric bipolar disorder. A treatment procedure informed by cognitive-behavioural, narrative and family...

olanzapine is the frequently prescribed drug in children and adolescents with bipolar disorder, but unfortunately it has metabolic side-effects. on the other hand, in a number of melatonin studies on sleep cycle, regulation of metabolic abnormalities has been reported. therefore, we aimed to study effects of melatonin in reducing metabolic side-effects of olanzapine in 11-17 year-old patients w...

54-year-old male patient was admitted in endocrine ward and referred to our hospital for psychiatric consult due to malaise symptoms , dysphoric mood, irritability, insomnia, loss of appetite, increasing the amount of speech, lack of enjoyment of life, hopelessness, thoughts of worthlessness ,thoughts of death (these symptoms was started from 4 months ago ,after some career change ). other symp...

This paper consists of a case history and an overview of the relationship, aetiology, and treatment of comorbid bipolar disorder migraine patients. A MEDLINE literature search was used. Terms for the search were bipolar disorder bipolar depression, mania, migraine, mood stabilizer. Bipolar disorder and migraine cooccur at a relatively high rate. Bipolar II patients seem to have a higher risk of...

Bipolar disorder is characterized by a hypersensitivity to reward-relevant cues and a propensity to experience an excessive increase in approach-related affect, which may be reflected in hypo/manic symptoms. The present study examined the relationship between relative left-frontal electroencephalographic (EEG) activity, a proposed neurophysiological index of approach-system sensitivity and appr...