نتایج جستجو برای: biophysical chemistry laboratory bcl
تعداد نتایج: 427104 فیلتر نتایج به سال:
The anti-apoptotic B-cell CLL/lymphoma-2 (Bcl-2) protein and its counterpart, the pro-apoptotic Bcl-2-associated X protein (Bax), are key players in the regulation of the mitochondrial pathway of apoptosis. However, how they interact at the mitochondrial outer membrane (MOM) and there determine whether the cell will live or be sentenced to death remains unknown. Competing models have been prese...
PEPTIDE-1 RECEPTOR EXTRACELLULAR DOMAIN Steffen Runge, Henning Thøgersen, Kjeld Madsen, Jesper Lau and Rainer Rudolph. From Department of Structure and Biophysical Chemistry and Department of Protein and Peptide Chemistry, Novo Nordisk, 2760 Måløv, Denmark. Institute of Biotechnology, Martin-Luther University, Halle-Wittenberg, 06120 Halle (Saale), Germany. Address correspondence to: Steffen Ru...
Biophysical Investigations of Boranophosphate siRNA for use in RNA Interference Against Human Disease by Laura Moussa Department of Chemistry Duke University Date: _______________________ Approved: ___________________________ Barbara Ramsay Shaw, Supervisor ___________________________ Richard MacPhail ___________________________ Boris Akhremitchev ___________________________ Jiyong Hong An abst...
We have characterized the molecular basis of the interaction between ASPP2 and Bcl-2, which are key proteins in the apoptotic pathway. The C-terminal ankyrin repeats and SH3 domain of ASPP2 (ASPP2(Ank-SH3)) mediate its interactions with the antiapoptotic protein Bcl-2. We used biophysical and computational methods to identify the interaction sites of Bcl-2 and its homologues with ASPP2. Using p...
PULSE Institute, SLAC National Accelerato Park, California 94025, USA. E-mail: kaspe edu Department of Chemical Physics, Lund Univ Centre for Molecular Movies, Department of DK-2800, Lyngby, Denmark LCLS, SLAC National Accelerator Laborato Theoretical Chemistry Division, Lund Unive Department of Chemistry, Stanford Univers Max Planck Institute for Biophysical Chem SSRL, SLAC National Accelerato...
Pro-survival members of the Bcl-2 protein family inhibit cell death by binding short helical BH3 motifs in pro-apoptotic proteins. Mammalian pro-survival proteins Bcl-x(L), Bcl-2, Bcl-w, Mcl-1, and Bfl-1 bind with varying affinities and specificities to native BH3 motifs, engineered peptides, and small molecules. Biophysical studies have determined interaction patterns for these proteins, parti...
1 cAMP modulates intracellular Ca sensitivity of fast-releasing synaptic vesicles at 2 the calyx of Held synapse 3 4 Lijun Yao, Takeshi Sakaba 5 6 7 Independent junior research group of biophysics of synaptic transmission, Max Planck 8 Institute for Biophysical Chemistry 9 Am Fassberg 11, 37077, Göttingen, Germany 10 11 12 Running title: cAMP potentiates neurotransmitter release 13 14 15 Corres...
پیش زمینه: بیان بیش از حد bcl-2 به طور مکرر در انواع مختلفی از سرطانها مشاهده شده و یکی از مارکرهای پیش آگاهی در سرطان پستان می باشد. نقش دوگانه bcl-2 در مهار هر دو مسیر مرگ سلولی آپوپتوز و اتوفاژی دلیل مهم انتخاب آن به عنوان یک هدف درمانی ایده ال می باشد. بنابراین، مورد هدف قرار دادن نشانگر bcl-2 ممکن است به عنوان یک استراتژی انتخابی برای بهبود اثر بخشی درمان و غلبه بر مقاومت دارویی برای شیمی ...
the original biophysical profile is time consuming and costly. this study was performed to compare diagnostic value of the original fetal biophysical profile to the modified biophysical profile. patients were selected from high risk pregnancies referred for fetal assessment and were randomly assigned to two groups. the measures of outcomes were perinatal mortality, cesarean section for abnormal...
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