After analyzing the Lauha Bhasma samples qualitatively and quantitatively, in-vivo studies on healthy adult male rabbits were carried out. Randomly selected anaemic rabbits were divided into different groups and three variants of Lauha Bhasma and ferrous sulphate sample were administered to each group. The effect of each formulation was monitored by measuring the haemoglobin (Hb) content spectr...

In drug discovery, time and resource constraints necessitate increasingly early decision making to accelerate or stop preclinical programs. Early discovery drug candidates may be potent inhibitors of new targets, but all too often exhibit poor pharmaceutical or pharmacokinetic properties that limit the in vivo exposure. Low solubility of a drug candidate often leads to poor oral bioavailability...

To evaluate the bioavailability of a new theophylline preparation suitable for once-a-day (od) oral administration, we performed a nonrandomized crossover study in which the absorption of the OD and a standard twice-a-day (bid) preparation were compared. Eight stable asthmatic patients, after having achieved steady-state, received an average of 975 mg of OD preparation at 8 PM. The protocol was...

Scaffolds are defined as the core structure of a molecule connecting different substituents or functional groups. Defining bioisosteric alternative scaffolds for lead structures is an important task in drug design to improve e.g. the activity, bioavailability or selectivity of the structures concerned [1]. In this context, bioisosteric replacement means changing the scaffold structure while ret...

BACKGROUND Lead (Pb) is a toxic element that occurs in elevated concentrations in soils, mostly as a result of anthropogenic activities. This study assess the Pb bioavailability in soils from two areas with different contamination level using Diffusive Gradients in Thin-Films (DGT) technique, single extractions and metal contents of vegetables grown on contaminated soils. RESULTS In the area ...

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In this study the chemical composition and iron bioavailability of hull and hull-less soybean flour from the new cultivar UFVTN 105AP was evaluated. The hemoglobin depletion-repletion method was used in Wistar rats. Soybean hull flour presented 37% more total dietary fiber and higher content of iron than hull-less soybean flour. The phytate:iron molar ratio, however, was 2-fold lower in the soy...