Bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics have been increasingly used in chemosensing and bioimaging due to their high sensitivity, photostability and biocompatibility. In this review, we summarize the design of cellular organelle specific (cytoplasm membrane, mitochondria, lysosomes, lipid droplets and nucleus) AIE bioprobes and their applications in...

We report multifunctional optical imaging using dye-coated gold nanorods. Three types of useful information, namely, Raman, fluorescence signals, and absorption contrast, can be obtained from a phantom experiment. These three kinds of information are detected in a nanoparticle-doped-phantom using diffuse optical imaging. Our novel nanoparticle could be used as a multimodality marker for future ...

A sulfane sulfur mediated benzodithiolone formation was developed. Based on this reaction, two fluorescent probes (SSP1 and SSP2) for the detection of sulfane sulfur species (persulfide, polysulfide, and elemental sulfur) were prepared and evaluated. The probes showed high selectivity and sensitivity to sulfane sulfurs. Moreover, SSP2 was successfully applied for bioimaging sulfane sulfurs in l...

David Nam1 [email protected] Judith Mantell2,3 [email protected] David Bull1 [email protected] Paul Verkade2,3,4/shared last author [email protected] Alin Achim1 [email protected] 1 Visual Information Laboratory University of Bristol, UK 2 Wolfson Bioimaging Facility University of Bristol, UK 3 School of Biochemistry University of Bristol, UK 4 School of Physiology an...

Hydrophilic mesoporous carbon nanoparticles (MCNs) have been synthesized via an extremely facile precursor carbonization-in-hot solvent route. The synthesized MCNs show well-defined particle and pore size distribution at around 100 nm and 2.7 nm, respectively, and multicolor and upconversion photoluminescence, which endow the MCNs with multicolor/upconversion bioimaging and drug delivery proper...

We present a simple method for preparing water dispersible NaGdF4: Yb3+, Er3+/silica/gold nanoparticles. The emission intensity and color of the upconverting cores are modulated by the plasmonic absorbance and field enhancement from the gold nanoparticles. The applicability of hybrid NPs for multi-modal bioimaging probes is illustrated by in vitro confocal microscopy of living cancer cells.

H. P. Ng, M. Kubicki, D. Terry, P. Pelavin, A. Rausch, and M. E. Shenton Psychiatry Neuroimaging Lab, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, -, Singapore, Clinical Neuroscience Division, VA Boston Healthcare System, Harvard Medical School, Brockton, Massa...

In Drosophila, the neuropeptide PDF is required for circadian rhythmicity, but it is unclear where PDF acts. In this issue of Neuron, Shafer et al. use a novel bioimaging methodology to demonstrate that PDF elevates cAMP in nearly all clock neurons. Thus, PDF apparently exerts more widespread effects on the circadian clock network than suggested by previous studies of PDF receptor expression.

1Department of Pharmaceutical Sciences and Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad, Pakistan 2Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore 54600, Pakistan 3Division of Biophysics, Department of Basic Medical Sciences, School of Medicine, Bahçeşehir University, Turkey 4Institute of Biostructu...