The most promising drug delivery systems today are biodegradable microspheres and microcapsules. Microspheres can be injected subcutaneously or intramuscularly, adapted for oral administration or inhalation, and introduced into the bloodstream (Ueda 2003). The rapid development of microencapsulation has triggered an interest in biocompatible and biodegradable polyhydroxyalkanoates (PHAs), which...

     In this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (PLGA 50:50) and poly (lactide). The effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation effic...

This master’s thesis is a part of ‘Human Spare Parts’ research program by BioMediTech. The aim of the research program is to integrate different branches of biomedical engineering and stem cell research to discover new and better therapies and treatments. However, this thesis concentrates on biomaterials and sensor technology. The first part of the thesis, entitled the theoretical part is dedic...

ANNI ANTNIEMI: Evaluation of the feasibility of biodegradable polymers for encapsulating resonance circuits Tampere University of Technology Master of Science Thesis, 63 pages, 1 Appendix page June 2016 Master’s Degree Programme in Material Science Major: Biomaterials Examiner: Professor Minna Kellomäki

Incorporation of orthogonal functional groups into biodegradable polymers permits the fabrication of multi-layered thin films with improved adhesion and tunable degradation profiles. The bi-layer structure also allows for accurate control over small molecule release.

There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by an enzymatic route, bearing a hydroxyl group that can be further functionalized. Polymers with an average Mn of ∼13 ...

Oral route is the most preferred route for administration of different drugs because it is regarded as safest, most convenient, and economical route. Fast disintegrating tablets are very popular nowadays as they get dissolved or facilely disintegrated in mouth within few seconds of administration without the need of water. The disadvantages of conventional dosage form, especially dysphagia (ard...

Aliphatic biodegradable polyesters have been the most widely used synthetic polymers for developing biodegradable devices as alternatives for the currently used permanent medical devices. The performances during biodegradation process play crucial roles for final realization of their functions. Because physiological and biochemical environment in vivo significantly affects biodegradation proces...

Microspheres of biodegradable polymers were evaluated as a potential controlled-release drug-delivery system in the vitreous. The microspheres were prepared with polymers of poly(lactic acid) or copolymers of glycolic acid and lactic acid. The release of 5-fluorouracil (5-FU) from the microspheres was studied in vitro. Poly(lactic acid) microspheres released 70-85% of total 5-FU over 7 days. Mi...