Vertical nanowire arrays can be used for both energy harvesting and storage. Using assembly to create such arrays allows two populations to be mixed together, while standard fabrication limits the product to a single material. However in the absence of applied fields [1] or controlled drying conditions [2], nanowires typically assemble parallel to the surface, forming horizontal arrays. The Kea...

The development of a reaction for detecting the presence/absence of one methyl group in a long DNA strand is a chemically and biologically challenging research subject. A newly designed chemical assay on a chip for the typing of DNA methylation has been developed. A methylation-detection probe fixed at the bottom of microwells was crosslinked with methylated DNA mediated by osmium complexation ...

We propose a fabrication method of vertical and high-aspect-ratio microfluidic device which is made of borosilicate glass. Glass microfluidic devices have high demand because of its chemical stability, good bio compatibility, and high optical transparency. We realized vertical glass microwells of 25 μm in diameter and 50 μm in depth(aspect ratio: 2), and micropillars of 3 μm in diameter and 25 ...

Thrombocytopenia is a known potential side effect of hemodialysis, however, it is rarely seen in patients who undergo hemodialysis using biocompatible membranes. This case demonstrates hemodialysis-associated thrombocytopenia with use of biocompatible dialysis membranes that expose blood directly to polysulfone. The thrombocytopenia resolved in this patient when the dialysis membrane was change...

Recently, various approaches for controlling the embryonic stem (ES) cell microenvironment have been developed for regulating cellular fate decisions. It has been reported that the lineage specific differentiation could be affected by the size of ES cell colonies and embryoid bodies (EBs). However, much of the underlying biology has not been well elucidated. In this study, we used microengineer...

We report a new technique for the continuous and real-time measurement of microparticle-induced cellular responses using a real-time cell-electronic sensing (RT-CES) technology. The method involves the use of microelectrode-embedded microwells seeded with one of two lung cancer carcinoma cell lines (A549 and SK-MES-1), allowing for continuous measurements of impedance. The change in impedance t...