Diagnosis using a specific tumor marker is difficult because the sensitivity of this detection method is under 20%. Herein, a tumor marker combination assay, combining growth-related tumor marker and associated tumor marker (Cancer, 73(7), 1994), was employed. This double-blind tumor marker combination assay (TMCA) showed 87.5% sensitivity as the results, but a low specificity, ranging from 30 ...

Changes in osteoarthritis joint appear in the articular cartilage, synovium and in subchondral bone. It is necessary to find, apart from markers of cartilage destruction, a sensitive and specific biochemical marker which would reflect the metabolism as well as degradation of subchondral bone. Bone sialoprotein is mostly synthesized in osseous tissue found directly under the surface of joint car...

Abstract Background Elevated levels of S-100B in serum are increasingly considered a potential biochemical marker nervous system damage. To our knowledge, limited number research studies have tested the protein children with epilepsy. The objective study is to measure pediatric cases Results mean concentration was 0.135 ± 0.014 mg/L patient group and 0.082 0.018 control group. patients showed s...

Abstract Background The pathogenesis of type 2 diabetes mellitus (T2DM) originates from multiple tissue defects. Environmental pollutants such like endocrine-disrupting chemicals (EDCs) have lately gotten special attention in triggering the metabolic abnormalities relation to insulin resistance and T2DM. Bisphenol-A (BPA), which is one EDCs simulates natural endogenous estrogens, has been impli...

BACKGROUND Biological covariates such as age and sex can markedly influence biochemical marker reference values, but no comprehensive study has examined such changes across pediatric, adult, and geriatric ages. The Canadian Health Measures Survey (CHMS) collected comprehensive nationwide health information and blood samples from children and adults in the household population and, in collaborat...