With information constantly bombarding the human sensory systems, how is it that we attend to behaviorally relevant information? The present study examined the behavioral and neural bases of attending to one sense while ignoring another sense (bimodal selective attention) contrasted with attending simultaneously to two senses (bimodal divided attention). In a functional magnetic resonance imagi...

The relationship between salt bridges and stability/enzymatic activity is unclear. We studied this relationship by systematic alanine-scanning mutation analysis using the typical M4 family metalloprotease Pseudomonas aeruginosa elastase (PAE, also known as pseudolysin) as a model. Structural analysis revealed seven salt bridges in the PAE structure. We constructed ten mutants for six salt bridg...

A recent study has proposed that posterior regions of the medial frontal cortex (pMFC) learn to predict the likelihood of errors occurring in a given task context. A key prediction of the error-likelihood (EL) hypothesis is that the pMFC should exhibit enhanced activity to cues that are predictive of high compared with low error rates. We conducted 3 experiments, 2 using functional neuroimaging...

Learning novel skills involves reorganization and optimization of cognitive processing involving a broad network of brain regions. Previous work has shown asymmetric costs of switching to a well-trained task vs. a poorly-trained task, but the neural basis of these differential switch costs is unclear. The current study examined the neural signature of task switching in the context of acquisitio...

According to the modulation hypothesis, arousal is the crucial factor in the emotional enhancement of memory (EEM). However, the multifactor theory of the EEM recently proposed that cognitive characteristics of emotional stimuli, e.g., relatedness and distinctiveness, also play an important role. The current study aimed to investigate the individual contribution of arousal to the neural correla...

the present study was conducted to investigate the clinical effects and possible side effects of yarrow extract ( achillea millefolium l.) as feed additive on biochemical blood parameters and growth performance of rainbow trout ( oncorhynchus mykiss ). fishes were treated with 0 (control), 0.1, 0.5 and 1% of yarrow extract for 30 days. plasma alanine aminotransferase (alt), aspartate aminotrans...

Late long-term potentiation (L-LTP) denotes long-lasting strengthening of synapses between neurons. L-LTP appears essential for the formation of long-term memory, with memories at least partly encoded by patterns of strengthened synapses. How memories are preserved for months or years, despite molecular turnover, is not well understood. Ongoing recurrent neuronal activity, during memory recall ...

Deep quantum chemistry is a theory of deeply structured quantum fields carrying the biological information of the cell, making it able to remember, intend, represent the inner and outer world for comparison, understand what it "sees", and make choices on its structure, form, behavior and division. We suggest that deep quantum chemistry gives the cell consciousness and all the qualities and abil...