In continuation of our search for new bioactive compounds from soil microbes, a fluorescent Pseudomonas strain isolated from paddy field soil of Kuttanad, Kerala, India was screened for the production of bioactive secondary metabolites. This strain was identified as Pseudomonas mosselii through 16S rDNA gene sequencing followed by BLAST analysis and the bioactive metabolites produced were purif...

background: the appearance of multi-drug resistant microorganisms is becoming a global problem. already several strategies have been employed for overcoming antibiotic resistance issue. developing new antimicrobial compounds from microbial source could be a beneficial solution. hence screening programs in order to discover new antibiotics from microbial entities is interesting. because of high ...

Inspired by the multifunctionality of vitamin D-binding protein and the multiple transient-binding behavior of some intrinsically disordered proteins (IDPs), a polymeric platform is designed, prepared, and characterized for combined delivery of dermal protective and anticancer bioactive cargos on the basis of artificial single-chain nano-objects mimicking IDPs. For the first time ever, simultan...

Maslinic acid is a pentacyclic triterpene found in plants used in traditional medicine with antidiabetic, antitumor, antioxidant and parasitostatic activities. A diet rich in foods of plant origin could provide a regular supply of this bioactive compound since it has been detected in olives, spinaches, eggplants, chickpeas and pomegranates. The multiple biological effects elicited by maslinic a...

Inherent biological viability and diversity of natural products make them a potentially rich source for new therapeutics. However, identification of bioactive compounds with desired therapeutic effects and identification of their protein targets is a laborious, expensive process. Extracts from organism samples may show desired activity in phenotypic assays but specific bioactive compounds must ...

This study investigated the effect of green house conditions (temperature and soil moisture) on soybean [Glycine max (L.) Merr.] seeds bioactive compound concentrations. The analyses included plant characters and bioactive compounds contents. There were a good relationship between maturity date and total sphingolipids. Jack and Queen, among the latest and earliest had maturing entries, respecti...

objectives: securinega virosa roxb (ex willd) baill (euphorbaiceae) root bark has been reportedly used in african traditional medicine in the management of mental illnesses. previously, the sleep-inducing potential of the crude methanol root bark of securinega virosa extract and its butanol fraction have been reported. the study aimed to isolate and characterize the bioactive constituent that m...

background and objectives: due to the importance of finding of new antibacterial agents, the antibacterial properties of prosopis cineraria aerial parts were investigated using a bioassay guided fractionation scheme. materials and methods: the organic extract was prepared via maceration in methanol, followed by the fractionation using n-hexane and ethyl acetate. the mics of fractions were deter...

Traditional medicine is the synthesis of therapeutic experience of generations of practicing physicians of indigenous systems of medicine. Throughout the history of mankind, many infectious diseases have been treated with herbals. The traditional medicine is increasingly solicited through the tradipractitioners and herbalists in the treatment of infectious diseases. Among the remedies used, pla...