The AcrB trimeric multidrug efflux transporter of Escherichia coli pumps out a very wide spectrum of compounds. Although minocycline and doxorubicin have been cocrystallized within the large binding pocket in the periplasmic domain of the binding protomer, nothing is known about the binding of many other ligands to this protein. We used computer docking to evaluate the interaction of about 30 c...

We studied the effect on breathing of a conventional and a newly designed abdominal binder in seven patients with complete tetraplegia. The indices of respiratory ability used were the transdiaphragmatic pressure on maximal sniff (sniff Pdi), the maximum static inspiratory mouth pressure (PImax), and the vital capacity (VC). These were measured in patients with and without binders, in the supin...

In contrast to the low-level use of silicone polymers as additives, silicone resins can be major components of the coating. Here they are used as binders or co-binders, imparting important benefits such as durability throughout the life of the coating. Silicone resins offer resistance to weathering in paints for exterior surfaces such as bridges and metal cladding on buildings. They also provid...

Nominal techniques were introduced to represent in a simple and natural way systems that involve binders. The syntax includes an abstraction operator and a primitive notion of name swapping. Nominal matching is matching modulo α-equality, and has applications in programming languages and theorem proving, amongst others. In this paper we describe efficient algorithms to check the validity of equ...

Prediction of peptides binding with MHC class II allele HLA-DRB1(*)0401 can effectively reduce the number of experiments required for identifying helper T cell epitopes. This paper describes support vector machine (SVM) based method developed for identifying HLA-DRB1(*)0401 binding peptides in an antigenic sequence. SVM was trained and tested on large and clean data set consisting of 567 binder...

Code generation is the leading approach to making high-performance software reusable. Effects are indispensable in code generators, whether to report failures or to insert let-statements and ifguards. Extensive painful experience shows that unrestricted effects interact with generated binders in undesirable ways to produce unexpectedly unbound variables, or worse, unexpectedly bound ones. These...